{"id":"W7052340328","doi":"","title":"The search for inhibitors of O-acetylpeptidoglycan esterase 1a (Ape1a) in Neisseria gonorrhoeae","year":2009,"lang":"en","type":"dissertation","venue":"The Atrium (University of Guelph)","topic":"Electromagnetic Compatibility and Measurements","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Esterase; Enzyme; Neisseria gonorrhoeae; Drug discovery; Viability assay; Antibiotics; Cell; High-throughput screening; Nucleic acid","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001801319,0.0003598437,0.0004468113,0.0003144907,0.0001781124,0.000392176,0.0003390324,0.0003886688,0.001103348],"category_scores_gemma":[0.000169372,0.0001741409,0.00030943,0.0002607596,0.0001160004,0.0001810524,0.0002010569,0.0004645805,0.000329986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003175342,"about_ca_system_score_gemma":0.0003820799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001387109,"about_ca_topic_score_gemma":0.003409811,"domain_scores_codex":[0.9999201,0.000008411241,0.000004459659,0.00001287217,0.00003888124,0.00001536642],"domain_scores_gemma":[0.9999363,0.00001320744,0.00001751995,0.00000415672,0.00001567477,0.00001317802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002516515,0.0001918634,0.00088479,0.0003399513,0.00003878756,0.0002431838,0.00006197655,0.0006793233,0.9618215,0.0001873682,0.0003825246,0.03491702],"study_design_scores_gemma":[0.0001436487,0.005322272,0.008388116,0.00008459602,0.0002036456,0.001102586,0.000109942,0.00187326,0.9407716,0.0001273604,0.04184653,0.00002640609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9405863,0.04326307,0.005662767,0.0007555282,0.0001157392,0.0004236209,0.001033138,0.0001687659,0.007991041],"genre_scores_gemma":[0.9356946,0.04134747,0.00900468,0.0003662295,0.00005956002,0.0001693537,0.001958265,0.00002241561,0.01137743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001387109,"threshold_uncertainty_score":0.003691018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01328287516601891,"score_gpt":0.2191818410221128,"score_spread":0.2058989658560939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}