{"id":"W7055728606","doi":"","title":"Differential Regulation of hERG Current and Expression by Activation of Protein Kinase C Using Phorbol Ester Treatment","year":2018,"lang":"en","type":"dissertation","venue":"QSpace (Queen's University Library)","topic":"Magnetic confinement fusion research","field":"Physics and Astronomy","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"hERG; Protein kinase C; Potassium channel; Ubiquitin ligase; Protein kinase A; Patch clamp; Protein subunit; Phorbol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002097105,0.0003459446,0.000316334,0.0002567236,0.000164963,0.0004134599,0.0002394317,0.0003304774,0.00153588],"category_scores_gemma":[0.0001254359,0.00013754,0.0004527215,0.000344441,0.0002558746,0.0003655722,0.0002439784,0.0007819713,0.0004532945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000495749,"about_ca_system_score_gemma":0.0002775273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007173929,"about_ca_topic_score_gemma":0.001036063,"domain_scores_codex":[0.999694,0.00002591356,0.00003075897,0.00007593702,0.00006060241,0.0001127398],"domain_scores_gemma":[0.999881,0.00002642194,0.00002258833,0.00001796415,0.00002090309,0.00003103388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001413505,0.00002933852,0.00005555083,0.0000252775,0.000002652592,0.00002624671,0.00001147681,0.00001924397,0.9989926,0.00004717043,0.00002311249,0.0006259702],"study_design_scores_gemma":[0.00001776948,0.000137074,0.003351141,0.000004599399,0.00001075004,0.0000682691,0.00002034159,0.0004120831,0.9944766,0.00002865362,0.001468757,0.000004011858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876846,0.003571986,0.005103318,0.0002170268,0.0001049083,0.0000750842,0.0006724143,0.0001374417,0.002433229],"genre_scores_gemma":[0.9832201,0.003009845,0.00549047,0.0001573364,0.00003679838,0.0001993533,0.001411321,0.00004767254,0.006427154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00153588,"threshold_uncertainty_score":0.005138099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008870829916858123,"score_gpt":0.2250352702569128,"score_spread":0.2161644403400546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}