{"id":"W7057194564","doi":"","title":"Human iPSC-derived RPE and retinal organoids reveal impaired alternative splicing of genes involved in pre-mRNA splicing in PRPF31 autosomal dominant retinitis pigmentosa","year":2018,"lang":"en","type":"article","venue":"UWE Research Repository (UWE Bristol)","topic":"Magnetic confinement fusion research","field":"Physics and Astronomy","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universidad de Antioquia; Queen's University Belfast; Cardiff University; National League for Nursing; Australian Nurse Teachers' Society; Queen's University","keywords":"Retinitis pigmentosa; Cilium; Retinal pigment epithelium; Induced pluripotent stem cell; Retinal degeneration; Retinal; RNA splicing; Phenotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002347969,0.0002122433,0.0002140257,0.0002725935,0.0001609366,0.0002695617,0.0001514268,0.0004543562,0.001243494],"category_scores_gemma":[0.0001509098,0.0001605673,0.0002639339,0.0001498051,0.0002074912,0.0001234845,0.0002222069,0.0003877362,0.0005541943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001541389,"about_ca_system_score_gemma":0.0001063667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006335126,"about_ca_topic_score_gemma":0.0005624745,"domain_scores_codex":[0.9998242,0.00002295476,0.00002989642,0.00003213661,0.00007059399,0.00002024064],"domain_scores_gemma":[0.9998729,0.00003739438,0.00002642629,0.00003444587,0.000013961,0.00001476664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000352131,0.000007863761,0.0001514957,0.00001657507,0.000004065307,0.0002911796,0.00003555066,0.00007746834,0.9984304,0.000120748,0.00002885861,0.0008004931],"study_design_scores_gemma":[0.00001244594,0.0001273673,0.006058923,0.0000117759,0.00002612337,0.002292771,0.00006979626,0.0008722499,0.9871016,0.0001416381,0.003277533,0.000007882999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867913,0.001189226,0.007263014,0.0001070974,0.00003773401,0.00004411073,0.001110012,0.000188205,0.003269334],"genre_scores_gemma":[0.9916317,0.0006049078,0.003527681,0.00005785779,0.000004428238,0.00003509169,0.001199626,0.00003857278,0.002900209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001243494,"threshold_uncertainty_score":0.004159927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02715187091616227,"score_gpt":0.3212190018687899,"score_spread":0.2940671309526277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}