{"id":"W7061627420","doi":"","title":"Protein misfolding toxicity and inclusion formation in cellular models of neurodegeneration","year":2021,"lang":"en","type":"article","venue":"Scholarship@Western (Western University)","topic":"Magnetic confinement fusion research","field":"Physics and Astronomy","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Strong; ALS Society of Canada","keywords":"Neurodegeneration; Proteotoxicity; Huntingtin; Proteostasis; Amyotrophic lateral sclerosis; Protein aggregation; Inclusion bodies; Protein folding; Huntingtin Protein; Yeast","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003371498,0.0006214112,0.0004492626,0.0006188396,0.0003708931,0.0005124921,0.0004760453,0.0005439749,0.0007947501],"category_scores_gemma":[0.00008190363,0.0001657122,0.0003659319,0.0005196785,0.0003995329,0.0003219426,0.0004503296,0.0009925474,0.0003654848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006024931,"about_ca_system_score_gemma":0.000334263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001577052,"about_ca_topic_score_gemma":0.002343849,"domain_scores_codex":[0.9995878,0.0001040643,0.00004208676,0.00006329078,0.0001529899,0.0000496976],"domain_scores_gemma":[0.9998907,0.00001664626,0.00002791552,0.000023384,0.00002143274,0.00001997535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001876232,0.0001635711,0.0001973827,0.0001493575,0.00001403253,0.0001556834,0.0001184649,0.0003486331,0.9965012,0.0006538103,0.000187135,0.001323138],"study_design_scores_gemma":[0.0000323218,0.001243969,0.002218385,0.00003199591,0.00003853956,0.0004455252,0.00009231539,0.001863335,0.9867626,0.0003020308,0.006955943,0.00001298039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9704356,0.006752513,0.014349,0.0003823722,0.0002465741,0.0003509976,0.002330007,0.0002995152,0.004853528],"genre_scores_gemma":[0.9604962,0.009431602,0.01842975,0.0001342897,0.00003686165,0.0007790371,0.002255857,0.00006186495,0.008374576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001577052,"threshold_uncertainty_score":0.004371464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06277510919490811,"score_gpt":0.2838127674233258,"score_spread":0.2210376582284177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}