{"id":"W7066225532","doi":"","title":"The genetic and epigenetic determinants of osteoporosis","year":2019,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Health and Medical Research Council; Medical Research Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust; Biotechnology and Biological Sciences Research Council; ZonMw; Sahlgrenska Universitetssjukhuset; Stiftelsen för Strategisk Forskning; Knut och Alice Wallenbergs Stiftelse; University of Bristol; Economic and Social Research Council; European Commission; Ernest Heine Family Foundation; McGill University; Vetenskapsrådet; Australian Government; Jewish General Hospital; Novo Nordisk; National Institute for Health and Care Research; Genome Canada; Natural Sciences and Engineering Research Council of Canada","keywords":"Epigenetics; Osteoporosis; Disease; Genetic variants; Population; DNA methylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006268349,0.0001880336,0.000226131,0.0003015013,0.0005471263,0.0006065703,0.0001861661,0.0003680782,0.01469767],"category_scores_gemma":[0.001079602,0.0002173798,0.0001025191,0.0002273304,0.0003177462,0.0002337245,0.0003865304,0.0009427058,0.002193902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00033736,"about_ca_system_score_gemma":0.0007657544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006511147,"about_ca_topic_score_gemma":0.01315302,"domain_scores_codex":[0.9998324,0.00002799763,0.000004012769,0.00003841258,0.00007202229,0.00002508103],"domain_scores_gemma":[0.999702,0.00007332713,0.00002224849,0.000007367617,0.00008599069,0.0001089361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0003276919,0.000164554,0.0101224,0.0004019616,0.00003426232,0.0006950219,0.002079925,0.0002988757,0.0222109,0.01624049,0.5892276,0.3581963],"study_design_scores_gemma":[0.00005107177,0.0001597349,0.05914936,0.0003408396,0.00005000773,0.0007611398,0.002370195,0.0001457741,0.00668165,0.006151701,0.9240957,0.00004278803],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.1325039,0.2169524,0.004998779,0.2936864,0.01650817,0.0002362595,0.001505819,0.00033005,0.3332782],"genre_scores_gemma":[0.1722784,0.09385331,0.002703131,0.01411776,0.00299049,0.0001415292,0.0003342952,0.0001417985,0.7134393],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01469767,"threshold_uncertainty_score":0.04916859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008039549446149702,"score_gpt":0.2340090597413466,"score_spread":0.2259695102951969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}