{"id":"W7066899452","doi":"","title":"The investigation of the kinin-kallikrein pathway in prion pathogenicity","year":2017,"lang":"en","type":"dissertation","venue":"Mspace (University of Manitoba)","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Scrapie; Neurodegeneration; Inflammation; Oxidative stress; Nitric oxide synthase; Superoxide dismutase; Gene isoform; Nitric oxide; Reactive oxygen species","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002603155,0.0001961097,0.0001805955,0.0003906413,0.0001520232,0.0002703448,0.0001477398,0.0004299702,0.0003353297],"category_scores_gemma":[0.0001085588,0.00006434402,0.0001071822,0.0001719686,0.0003037659,0.0004586479,0.0001981024,0.0003804631,0.00009494268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002112874,"about_ca_system_score_gemma":0.0002302515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003079318,"about_ca_topic_score_gemma":0.0002548708,"domain_scores_codex":[0.9999453,0.00001812528,0.000003500161,0.00000724431,0.000009765368,0.0000161564],"domain_scores_gemma":[0.999916,0.00002320794,0.00001913057,0.000003603882,0.00001381865,0.0000243251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006203002,0.00013345,0.004372508,0.0006306553,0.00002404369,0.001744198,0.0001419694,0.0003055367,0.9692743,0.002015546,0.0001433347,0.02059421],"study_design_scores_gemma":[0.0001406166,0.005596145,0.2642314,0.0004598381,0.0002680118,0.02015155,0.001673552,0.01048663,0.6409646,0.01898011,0.03694215,0.0001053621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8841022,0.110116,0.002627783,0.0004493741,0.0000450665,0.00003977882,0.00007219795,0.00002358119,0.002524097],"genre_scores_gemma":[0.9691644,0.02832591,0.001432554,0.00008747072,0.00004237293,0.00001165457,0.00006229232,0.000001369252,0.0008718964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004299702,"threshold_uncertainty_score":0.001532972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01099090259988738,"score_gpt":0.2067786835610378,"score_spread":0.1957877809611504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}