{"id":"W7067364185","doi":"","title":"Locus for severity implicates CNS resilience in progression of multiple sclerosis","year":2023,"lang":"en","type":"article","venue":"","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Novartis Institutes for BioMedical Research; Sanofi Genzyme; EMD Serono; Multiple Sclerosis Society of Western Australia; Mitsubishi Tanabe Pharma Corporation; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Fonds Wetenschappelijk Onderzoek; NIHR Cambridge Biomedical Research Centre; Multiple Sclerosis Society; Genentech; Vlaamse regering; National Multiple Sclerosis Society; International Progressive MS Alliance; TG Therapeutics; National Institutes of Health; Regeneron Pharmaceuticals; European Commission; Helsingin Yliopisto; Sun Yat-sen University; Biogen; Celgene; Alexion Pharmaceuticals; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Teva Pharmaceutical Industries; Idorsia Pharmaceuticals; Disarm Therapeutics; Sanofi; Eli Lilly and Company; Max-Planck-Gesellschaft; Bristol-Myers Squibb; Race to Erase MS; Multiple Sclerosis Society of Canada; Amgen; University of California, San Francisco; Bristol-Myers Squibb Foundation; Deutsche Forschungsgemeinschaft","keywords":"Multiple sclerosis; Locus (genetics); Disease; Central nervous system; Resilience (materials science)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002494977,0.0006183349,0.0004431845,0.001887245,0.0009915597,0.001186365,0.0005444579,0.0005639989,0.00519037],"category_scores_gemma":[0.01214194,0.0001832435,0.001048919,0.001338261,0.0008820296,0.0007231675,0.001695995,0.001087146,0.0001911136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004376606,"about_ca_system_score_gemma":0.0008431447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005183476,"about_ca_topic_score_gemma":0.005337063,"domain_scores_codex":[0.9982317,0.0008872534,0.000140112,0.0002534039,0.0002463407,0.0002412544],"domain_scores_gemma":[0.990945,0.002568484,0.003433656,0.00118703,0.0005948751,0.001270946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000696854,0.0001057249,0.9915006,0.00002440315,0.0003990819,0.0001970056,0.0006054965,0.0001216558,0.001617697,0.000588558,0.00008546289,0.00405738],"study_design_scores_gemma":[0.00000933952,0.0001987712,0.9980425,0.00001063642,0.0001058814,0.000169021,0.0003880011,0.0001198918,0.000244832,0.0005757993,0.000128983,0.000006416786],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976652,0.0001616218,0.0002337673,0.0002119318,0.000009924641,0.000006608034,0.0001312744,0.000007170614,0.001572648],"genre_scores_gemma":[0.9996676,0.00002084638,0.00009529283,0.00001130731,0.000006420042,0.00000193932,0.00004417178,0.000002128058,0.0001503111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00519037,"threshold_uncertainty_score":0.01736355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1180731264729999,"score_gpt":0.3836402503132988,"score_spread":0.265567123840299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}