{"id":"W7070785810","doi":"","title":"p66ShcA as a prognostic and mechanistic biomarker for responsiveness to PARP inhibitor combination therapies in poor outcome breast cancers","year":2019,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Mineralogy and Gemology Studies","field":"Earth and Planetary Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Strong; McGill University","keywords":"PARP inhibitor; Doxorubicin; Biomarker; Breast cancer; Viability assay; In vivo; Oxidative stress; Cell culture; DNA damage","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007209724,0.0003030069,0.0003538017,0.001131172,0.000209473,0.0007496183,0.0001888201,0.0004194363,0.001446406],"category_scores_gemma":[0.001019437,0.0001507156,0.0003220795,0.0007369751,0.000229114,0.0003552894,0.0003071038,0.0005867427,0.0003099866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002593194,"about_ca_system_score_gemma":0.000174568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000370403,"about_ca_topic_score_gemma":0.0005616843,"domain_scores_codex":[0.9997435,0.00006439076,0.00002950029,0.0000465616,0.000067258,0.0000487341],"domain_scores_gemma":[0.9993463,0.0001002468,0.0003127253,0.00004207779,0.00006301066,0.0001356192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005311778,0.0003066442,0.9217464,0.0001329064,0.000265999,0.0003954899,0.0001255476,0.0009415324,0.02851757,0.0001319598,0.0008538156,0.04127031],"study_design_scores_gemma":[0.00006525262,0.001421881,0.9847406,0.00003316446,0.0002294068,0.001144569,0.0001996902,0.002438212,0.007571809,0.0004004711,0.00173122,0.00002371817],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943197,0.002962792,0.00059256,0.0002327656,0.00003862846,0.00003477508,0.0004254384,0.0000432299,0.00135009],"genre_scores_gemma":[0.998657,0.0003903781,0.000267401,0.00003650304,0.0000301903,0.00001595188,0.0002792619,0.000002525408,0.0003207301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001446406,"threshold_uncertainty_score":0.004838705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02064442693482476,"score_gpt":0.2616169724636057,"score_spread":0.2409725455287809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}