{"id":"W7071145339","doi":"","title":"Regulation of the hepatic PI3K-Akt pathway and PTP1B expression by silencing Nck1","year":2016,"lang":"en","type":"dissertation","venue":"eScholarship@McGill (McGill)","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McGill University Health Centre; McGill University","keywords":"Gene silencing; Insulin resistance; Insulin; Insulin receptor; Signal transduction; Signal transducing adaptor protein; Knockout mouse; Glucose homeostasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001282576,0.0002735385,0.0001827382,0.000145717,0.0001600193,0.000333507,0.0002144726,0.0001681189,0.001126113],"category_scores_gemma":[0.0000864149,0.0001250166,0.000217493,0.0001554764,0.0002198911,0.0001912137,0.0001640129,0.0005806969,0.0003281982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003565419,"about_ca_system_score_gemma":0.0003021738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006867668,"about_ca_topic_score_gemma":0.001061536,"domain_scores_codex":[0.9998848,0.000009942303,0.00001563289,0.00003614083,0.00002363736,0.0000298143],"domain_scores_gemma":[0.9999225,0.000009577477,0.00003182081,0.000009864089,0.000008340186,0.00001786905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001404506,0.00002868448,0.0001874559,0.0000648686,0.000005460819,0.00002528528,0.00002037169,0.00008077718,0.997783,0.000178594,0.00006958502,0.001415464],"study_design_scores_gemma":[0.00002263735,0.0001228709,0.00309449,0.000007150874,0.00002009728,0.00007454836,0.00002931839,0.001018234,0.9931252,0.00003272172,0.002449102,0.000003594437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890677,0.002512243,0.004848174,0.0002036764,0.00008023994,0.00004307133,0.0005531205,0.0001227154,0.002568973],"genre_scores_gemma":[0.9912744,0.001719235,0.002676656,0.00004831356,0.00001267189,0.00008961294,0.0005199062,0.00002973655,0.003629478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001126113,"threshold_uncertainty_score":0.003767192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006004167804853172,"score_gpt":0.2109350298696524,"score_spread":0.2049308620647992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}