{"id":"W7071309535","doi":"","title":"siRNA-based breast cancer therapy by suppressing 17β-hydroxysteroid dehydrogenase type 1 in an optimized xenograft cell and molecular biology model in vivo","year":2019,"lang":"en","type":"other","venue":"Dove Medical Press (Taylor and Francis Group)","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Shanghai Institute Of Planned Parenthood Research; Shanghai Municipal Health and Family Planning Commission; Science and Technology Commission of Shanghai Municipality","keywords":"In vivo; Breast cancer; Estrone; Gene knockdown; Cancer; Estrogen receptor; Nuclease; Estrogen; Aromatase","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003110233,0.000537269,0.0005944847,0.0003737181,0.0002456312,0.0003177926,0.0003892239,0.0005225973,0.001403705],"category_scores_gemma":[0.00008698677,0.0002185252,0.0003991625,0.0002494779,0.0002324001,0.0003198769,0.0001447289,0.0008047927,0.0005432718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004645222,"about_ca_system_score_gemma":0.0006216078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002347515,"about_ca_topic_score_gemma":0.003669608,"domain_scores_codex":[0.9997798,0.00002496457,0.00002085086,0.00004959152,0.00007964752,0.00004520849],"domain_scores_gemma":[0.9999312,0.00001126435,0.00001556195,0.000009339401,0.00001394981,0.00001858886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001353153,0.0001323979,0.0000787649,0.00008165406,0.00001076908,0.00004353982,0.00002702794,0.0001822107,0.9959297,0.0002656936,0.0002977884,0.002815101],"study_design_scores_gemma":[0.00008164086,0.0006842584,0.0008997367,0.000008478914,0.00004852887,0.0001916391,0.00002725319,0.00287831,0.9880932,0.00006440223,0.007013522,0.000009021617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9291208,0.01197453,0.04435541,0.001072519,0.0006221643,0.0004499277,0.002079498,0.001176227,0.009148908],"genre_scores_gemma":[0.9519718,0.006730395,0.02382064,0.0003366979,0.00004323165,0.0006938424,0.001983691,0.0001279493,0.01429186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002347515,"threshold_uncertainty_score":0.004695892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009278304336787627,"score_gpt":0.2707600034785347,"score_spread":0.2614816991417471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}