{"id":"W7072346233","doi":"","title":"Whole genome sequence analysis of platelet traits in the NHLBI trans-omics for precision medicine initiative","year":2021,"lang":"en","type":"article","venue":"ScholarWorks @ UTRGV (The University of Texas Rio Grande Valley)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Deafness and Other Communication Disorders; National Cancer Institute; National Eye Institute; National Human Genome Research Institute; National Institute on Aging; National Blood Foundation; Kaiser Foundation Research Institute; University of Illinois at Urbana-Champaign; Johns Hopkins University; University of Minnesota; U.S. Department of Health and Human Services; COPD Foundation; Common Fund; GlaxoSmithKline; National Institutes of Health; San Diego State University; National Institute of Mental Health; National Heart, Lung, and Blood Institute; University of Miami; Biogen; Pfizer; Northwestern University; Medical Research Council; AstraZeneca; Canadian Institutes of Health Research; Sunovion; Andrea and Charles Bronfman Philanthropies; American Heart Association","keywords":"Genome-wide association study; Whole genome sequencing; Mendelian inheritance; Genetic association; Genetic variation; Gene; Blood Platelet Disorders; Precision medicine; Population; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001811595,0.0004021803,0.0007228433,0.001884389,0.0008069083,0.001318626,0.0006141769,0.0006285812,0.004483268],"category_scores_gemma":[0.003574761,0.0002424523,0.0009104988,0.005166032,0.0001326313,0.0001937733,0.001026908,0.00100961,0.001276905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006360018,"about_ca_system_score_gemma":0.001402852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02645494,"about_ca_topic_score_gemma":0.04813443,"domain_scores_codex":[0.998597,0.0003347917,0.0001484298,0.0003932792,0.0003659601,0.0001605872],"domain_scores_gemma":[0.99847,0.0003759072,0.0003140358,0.0002627391,0.000414926,0.0001624293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003209789,0.0001782873,0.5729401,0.001789707,0.005730646,0.002940028,0.001213493,0.002003855,0.06196401,0.003501507,0.2383595,0.1061691],"study_design_scores_gemma":[0.0006232384,0.000202505,0.8785683,0.0003703735,0.001813765,0.001634572,0.0003714659,0.002021201,0.003380278,0.001670489,0.1092778,0.00006583435],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"dataset","genre_gemma":"empirical","genre_scores_codex":[0.3865209,0.0077959,0.01315359,0.003292137,0.0002913862,0.0003248793,0.576721,0.0008028153,0.01109745],"genre_scores_gemma":[0.4066302,0.002786715,0.02440906,0.003605175,0.0002455816,0.0009887696,0.5563403,0.0004901456,0.004503939],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02645494,"threshold_uncertainty_score":0.05260187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03214732774437903,"score_gpt":0.2651724384582781,"score_spread":0.2330251107138991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}