{"id":"W7073533432","doi":"","title":"Phase 2b program with sonlicromanol in patients with mitochondrial disease due to m.3243A>G mutation.","year":2025,"lang":"en","type":"article","venue":"DZNE Pub","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"HORIZON EUROPE European Innovation Council; Julius Clinical; HORIZON EUROPE Framework Programme; Bundesministerium für Bildung und Forschung; E-Rare","keywords":"Placebo; Tolerability; Randomized controlled trial; Clinical endpoint; Mitochondrial disease; Randomization; Clinical trial","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002058142,0.001515985,0.001851411,0.0006382688,0.0004657821,0.0005896723,0.0007191662,0.001668861,0.009821955],"category_scores_gemma":[0.001311926,0.000569471,0.001359088,0.0002564726,0.0005638191,0.0006802668,0.0006513778,0.002080042,0.001468271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006469557,"about_ca_system_score_gemma":0.001542628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006990563,"about_ca_topic_score_gemma":0.001395357,"domain_scores_codex":[0.9994197,0.0003066286,0.00002886432,0.00008565772,0.00004664214,0.0001126175],"domain_scores_gemma":[0.9991574,0.0001619727,0.0001707625,0.00009194078,0.00009926286,0.0003186758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8371383,0.06123769,0.002647918,0.0007356345,0.0006066482,0.0001954371,0.0001485182,0.0009366888,0.02216688,0.0004146125,0.003834164,0.06993759],"study_design_scores_gemma":[0.6884208,0.3001022,0.004160644,0.000036982,0.0001943387,0.0001094764,0.0000286914,0.0004240235,0.002121575,0.0001874832,0.004196105,0.0000176853],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9401614,0.002656534,0.00257095,0.001157677,0.0003824908,0.04545751,0.003732634,0.0002475332,0.003633245],"genre_scores_gemma":[0.8864022,0.002614611,0.009549229,0.002999145,0.0007108706,0.08107313,0.005668501,0.00008210805,0.01090025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009821955,"threshold_uncertainty_score":0.03285772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00401176905771946,"score_gpt":0.2523228452361019,"score_spread":0.2483110761783824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}