{"id":"W7073533432","doi":"","title":"Phase 2b program with sonlicromanol in patients with mitochondrial disease due to m.3243A>G mutation.","year":2025,"lang":"en","type":"article","venue":"DZNE Pub","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"HORIZON EUROPE European Innovation Council; Julius Clinical; HORIZON EUROPE Framework Programme; Bundesministerium für Bildung und Forschung; E-Rare","keywords":"Placebo; Tolerability; Randomized controlled trial; Clinical endpoint; Mitochondrial disease; Randomization; Clinical trial","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003624586,0.0001645199,0.0001538423,0.0001125795,0.00005758478,0.00003573074,0.0001265388,0.00009046659,0.00003200521],"category_scores_gemma":[0.00006881629,0.000131063,0.00003663928,0.0002719923,0.00005056945,0.000006287538,0.00005122337,0.00008336738,0.00001970645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001664511,"about_ca_system_score_gemma":0.0001386176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001324062,"about_ca_topic_score_gemma":0.0001458834,"domain_scores_codex":[0.9989656,0.00005698699,0.0001718921,0.0004340475,0.000117923,0.0002535964],"domain_scores_gemma":[0.9993629,0.000007739898,0.00004533187,0.0003250433,0.0001170707,0.0001418429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1046965,0.02763657,0.3174268,0.0004193965,0.000837944,0.000977044,0.0008813597,0.001237458,0.1533096,0.00225954,0.1042508,0.2860669],"study_design_scores_gemma":[0.06641331,0.01807031,0.2063808,0.0002314039,0.0002346471,0.00002924488,0.0001924756,0.0001352437,0.04913753,0.0002080247,0.6573303,0.001636751],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992405,0.00004432831,0.004482049,0.0004693726,0.0004215353,0.00123514,0.00005578712,0.00003382375,0.0008529575],"genre_scores_gemma":[0.986536,0.000002851232,0.007580927,0.00159866,0.0003169958,0.000677316,0.001194737,0.0000324039,0.002060123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5530795,"threshold_uncertainty_score":0.5344594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00401176905771946,"score_gpt":0.2523228452361019,"score_spread":0.2483110761783824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}