{"id":"W7073671677","doi":"","title":"Magnetic Resonance Imaging Measures to Track Atrophy Progression in Progressive Supranuclear Palsy in Clinical Trials.","year":2024,"lang":"en","type":"article","venue":"DZNE Pub","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIH Clinical Center; University of Chicago Medicine; Newcastle upon Tyne Hospitals NHS Foundation Trust; University of California, San Francisco; Deutsches Zentrum für Neurodegenerative Erkrankungen; Universität Rostock; Centre Hospitalier Universitaire de Bordeaux; Servier; Eli Lilly and Company; Ludwig-Maximilians-Universität München; RWTH Aachen University; Humboldt-Universität zu Berlin; H. Lundbeck A/S; Eberhard Karls Universität Tübingen; Universidad de Navarra; Eisai; University of Toronto; University of Pennsylvania; Volkswagen Foundation; Technische Universität Dresden; Korea University; Deutsche Forschungsgemeinschaft; University of Cambridge; Johns Hopkins University; GHR Foundation; Ochsner Health; Indiana University Health; National Institutes of Health; Regeneron Pharmaceuticals; Rush University; University of South Florida; Pennsylvania State University; University of South Carolina; Massachusetts General Hospital; University of Minnesota; University of Ottawa; University of Chicago; Morsani College of Medicine; Korea University Guro Hospital; Bristol-Myers Squibb; Teva Pharmaceutical Industries; Pfizer; Biogen; Rheinische Friedrich-Wilhelms-Universität Bonn; Alzheimer's Association; Alzheimer's Disease Neuroimaging Initiative; Sanofi; Bayer Vital","keywords":"Progressive supranuclear palsy; Atrophy; Magnetic resonance imaging; Cohort; Third ventricle; Clinical trial","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04454806,0.001655914,0.003039203,0.001646344,0.0005899064,0.001725721,0.000968991,0.002083321,0.003731935],"category_scores_gemma":[0.03582671,0.0005604826,0.003397124,0.001779664,0.000803041,0.001494416,0.0008419437,0.002607367,0.0006377028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007786438,"about_ca_system_score_gemma":0.001291184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004894594,"about_ca_topic_score_gemma":0.001475728,"domain_scores_codex":[0.9638143,0.02830443,0.003538786,0.001532852,0.002348691,0.0004609592],"domain_scores_gemma":[0.9757154,0.01287334,0.006778812,0.001686508,0.002262846,0.0006829911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5500919,0.004489707,0.06942226,0.02526036,0.08037177,0.0002810707,0.0004614109,0.00594149,0.006529257,0.002556795,0.01537327,0.2392207],"study_design_scores_gemma":[0.4862891,0.1310969,0.2590061,0.003642508,0.05651067,0.0006828309,0.000270404,0.008270051,0.00558743,0.007941393,0.04043518,0.0002673932],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5546901,0.2942113,0.02770895,0.008303268,0.005048309,0.05649885,0.01836959,0.001283756,0.03388591],"genre_scores_gemma":[0.9189509,0.0141008,0.01912412,0.003656325,0.001079101,0.03589141,0.004407664,0.000104967,0.002684657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04454806,"threshold_uncertainty_score":0.2355954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07461813888897705,"score_gpt":0.4133576456263706,"score_spread":0.3387395067373936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}