{"id":"W7073692750","doi":"","title":"Prevalence of cerebral amyloid pathology in persons without dementia: A meta-analysis","year":2015,"lang":"en","type":"article","venue":"Archive ouverte UNIGE (University of Geneva)","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; Janssen Pharmaceuticals; National Institute on Aging; Instituto de Salud Carlos III; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis; Canadian Institutes of Health Research; National Institutes of Health; Région Normandie; H. Lundbeck A/S; Merz Pharmaceuticals; Vlaamse regering; IXICO; Turun Yliopistollinen Keskussairaala; Medical Research Council; Servier; Innovative Medicines Initiative; Center for Translational Molecular Medicine; National Institute of Biomedical Imaging and Bioengineering; Rigshospitalet; Kuopion Yliopistollinen Sairaala; Avid Radiopharmaceuticals; University of Pittsburgh; KU Leuven; Foundation for the National Institutes of Health; University of Southern California; Eisai; Deutsche Forschungsgemeinschaft; Technische Universität München; Institut National de la Santé et de la Recherche Médicale; Ministero della Salute; Fonds Wetenschappelijk Onderzoek; Medpace; Bundesministerium für Bildung und Forschung; Janssen Research and Development; ZonMw; Krajowy Naukowy Osrodek Wiodacy; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; U.S. Department of Defense; Commonwealth Scientific and Industrial Research Organisation; Bayer HealthCare; Genentech; Fondation pour la Recherche sur Alzheimer; AstraZeneca; European Commission; Pfizer; EU Joint Programme – Neurodegenerative Disease Research; Universiteit Antwerpen; Northern California Institute for Research and Education; National Research Centre; Agence Nationale de la Recherche; Biogen; BioClinica; University of California, San Diego; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Sundhed og Sygdom, Det Frie Forskningsråd; Indian Council of Medical Research; Lundbeckfonden; Eli Lilly and Company; Itä-Suomen Yliopisto; National Health and Medical Research Council; Edith Cowan University; F. Hoffmann-La Roche; Synarc; Bristol-Myers Squibb; European Regional Development Fund; Academy of Finland; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association; European Federation of Pharmaceutical Industries and Associations; Science and Industry Endowment Fund; Dementia Collaborative Research Centres, Australia; Belgian Federal Science Policy Office; National Science Foundation","keywords":"Dementia; Pathological; Amyloid (mycology); Apolipoprotein E; Disease; Cognition; Cognitive impairment; Alzheimer's disease; Biomarker","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005264928,0.0001449223,0.0007625798,0.0007686296,0.0000565751,0.000003380231,0.0002846431,0.00005731332,0.0009583168],"category_scores_gemma":[0.00005046008,0.0001472297,0.0006169207,0.0006315978,0.0003941848,0.0001231486,0.000241461,0.0001736923,0.00001636971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004556717,"about_ca_system_score_gemma":0.0002362722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006822895,"about_ca_topic_score_gemma":0.001240732,"domain_scores_codex":[0.998287,0.0003538381,0.0001870217,0.0003591344,0.0005055509,0.0003074914],"domain_scores_gemma":[0.998982,0.00005782793,0.0001501181,0.0003567398,0.0002333835,0.0002199732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005544717,0.0004807805,0.9526451,0.0001553865,0.03706777,0.0002116906,0.004551513,0.00003526068,0.003150469,0.0002173486,0.0005293653,0.0004008822],"study_design_scores_gemma":[0.003403969,0.00102094,0.8881069,0.00001729783,0.09417748,0.00001498351,0.008441032,0.003279948,0.0008129735,0.0002819808,0.000258299,0.0001841603],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789446,0.0004623244,0.01078772,0.0004319503,0.00001731666,0.0003971895,0.0001405144,0.00001401745,0.008804365],"genre_scores_gemma":[0.9912061,0.00009354269,0.005726557,0.00007049477,0.00000602008,0.000001308714,0.0000376213,0.000008284103,0.002850069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06453812,"threshold_uncertainty_score":0.9999549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0508424717814718,"score_gpt":0.2773387549199325,"score_spread":0.2264962831384607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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