{"id":"W7073707568","doi":"","title":"Identifying the Common Genetic Basis of Antidepressant Response","year":2022,"lang":"","type":"article","venue":"MPG.PuRe (Max Planck Society)","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"Janssen Research and Development; Taipei Veterans General Hospital; Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu; Hôpitaux Universitaires de Genève; Università di Bologna; National Health Research Institutes; University of Toronto; Kansai Medical University; Innovative Research Group Project of the National Natural Science Foundation of China; Lundbeckfonden; H. Lundbeck A/S; National Yang-Ming University; Aarhus Universitetshospital; University of Alberta; QIMR Berghofer Medical Research Institute; Sveučilište u Zagrebu; McGill University; Aarhus Universitet; Campbell Family Mental Health Research Institute; University of Pittsburgh; Dalhousie University; Medicinski Fakultet, Sveučilište u Zagrebu; Massachusetts General Hospital","keywords":"Antidepressant; Heritability; Schizophrenia (object-oriented programming); Major depressive disorder; Single-nucleotide polymorphism; Genetic association; Genetic correlation; Multifactorial Inheritance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002343216,0.0005448893,0.0009910755,0.000121015,0.001459619,0.0001022735,0.00111286,0.0002938845,0.001453395],"category_scores_gemma":[0.0009511631,0.0004642087,0.000912116,0.001159348,0.0005170521,0.0001098632,0.001445036,0.001848026,0.00005354919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002529206,"about_ca_system_score_gemma":0.0004541035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004878411,"about_ca_topic_score_gemma":0.00002759824,"domain_scores_codex":[0.9941546,0.001294224,0.001121478,0.0007759069,0.001663161,0.0009905943],"domain_scores_gemma":[0.9935926,0.003752456,0.0006823532,0.001512801,0.0001473345,0.0003124465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008106633,0.001708798,0.5740761,0.001557993,0.002579371,0.00143699,0.02576379,0.007148408,0.01484248,0.0006935574,0.3495846,0.01250128],"study_design_scores_gemma":[0.006832941,0.002261475,0.8708539,0.001322107,0.00267952,0.0006205671,0.02220357,0.01008431,0.00687617,0.0009222962,0.07406981,0.001273346],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.957798,0.03119901,0.0008245715,0.003456186,0.00205665,0.001137555,0.001274651,0.0001300291,0.002123345],"genre_scores_gemma":[0.9930069,0.00161893,0.001179395,0.001647766,0.0005658941,0.000105395,0.0001357179,0.0001004949,0.001639444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2967778,"threshold_uncertainty_score":0.9998403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02668702058605241,"score_gpt":0.2768875382563799,"score_spread":0.2502005176703275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}