{"id":"W7073974735","doi":"","title":"Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer's disease.","year":2024,"lang":"en","type":"article","venue":"DZNE Pub","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Fleni; Deutsches Zentrum für Neurodegenerative Erkrankungen; Korea Health Industry Development Institute; Japan Agency for Medical Research and Development; Fondation Brain Canada","keywords":"Disease; Dementia; Pathological; Degeneration (medical); Alzheimer's disease; Neuroimaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002960941,0.0001364481,0.0001857782,0.0001061481,0.000049879,0.00006504457,0.00006749512,0.00006656824,0.00009677253],"category_scores_gemma":[0.0003089117,0.0001175526,0.00008103497,0.0002031878,0.00004456333,0.0001725407,0.00008402547,0.0002028863,0.0001101545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005233117,"about_ca_system_score_gemma":0.00009842507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004915836,"about_ca_topic_score_gemma":0.00004234929,"domain_scores_codex":[0.9989079,0.00006394454,0.0002219577,0.0002837826,0.0002285146,0.0002938835],"domain_scores_gemma":[0.9993527,0.0001635998,0.00002560223,0.0002004898,0.00002025912,0.0002373551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001238971,0.0005785709,0.8702177,0.0003734529,0.0004382641,0.003279544,0.0004541151,0.0001156104,0.001262149,0.00416014,0.004340935,0.1135405],"study_design_scores_gemma":[0.0007580756,0.00006827575,0.9768454,0.0006812669,0.0004811521,0.0000766423,0.00003077226,0.0121056,0.0003580805,0.0006498895,0.007760398,0.0001844825],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823443,0.01183637,0.0008595469,0.002248704,0.0003240573,0.0003166672,0.0000481096,0.0001908346,0.001831378],"genre_scores_gemma":[0.9981756,0.0001199215,0.001019194,0.0001762761,0.0002141917,0.00003312213,0.0001721705,0.00002035936,0.00006915803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.113356,"threshold_uncertainty_score":0.4793656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02193511895126086,"score_gpt":0.2952667931217745,"score_spread":0.2733316741705136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}