{"id":"W7074076426","doi":"","title":"Functional live-cell imaging demonstrates that beta1-integrin promotes type IV collagen degradation by breast and prostate cancer cells.","year":2008,"lang":"en","type":"article","venue":"Scholarship at UWindsor (University of Windsor)","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"","keywords":"Matrix metalloproteinase; Extracellular matrix; Prostate cancer; Cathepsin; Basement membrane; Extracellular; Secretion; Proteolysis; Cathepsin L; Proteolytic enzymes","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001179284,0.0001785153,0.0001530336,0.00006776056,0.0004120187,0.00002228145,0.0001377133,0.0001561278,0.0002529544],"category_scores_gemma":[0.000009013493,0.0001990268,0.00006963895,0.0001318683,0.0002207939,0.00005935998,0.0001208573,0.000141312,0.00002350539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003728918,"about_ca_system_score_gemma":0.00009543342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001452817,"about_ca_topic_score_gemma":0.0001308784,"domain_scores_codex":[0.9990328,0.00006800773,0.00009793073,0.0003961036,0.0001879891,0.0002171799],"domain_scores_gemma":[0.9993917,0.00001117071,0.0001338328,0.0001806671,0.000169627,0.0001130051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000381081,0.00003958989,0.2987456,0.00002439177,0.00004624017,0.000006888769,0.0002199144,0.000007668465,0.6958326,0.000002733981,0.003609763,0.001083517],"study_design_scores_gemma":[0.00193214,0.0002827711,0.6238292,0.00004578086,0.0001397154,0.0001947123,0.001358881,0.0001021398,0.3635363,0.00004591297,0.008015696,0.000516772],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978898,0.0009269178,0.00005546454,0.0002677146,0.0001503161,0.0001857809,0.0001271983,0.00002017951,0.000376602],"genre_scores_gemma":[0.9939371,0.000438838,0.0004390125,0.00006270332,0.00006090984,5.652406e-7,0.0002712752,0.00002122163,0.004768325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3322963,"threshold_uncertainty_score":0.8116077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009998290346539606,"score_gpt":0.1836622242719175,"score_spread":0.1736639339253779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}