{"id":"W7074120617","doi":"","title":"Disposition kinetics and metabolism of nicotine and cotinine in African American smokers: Impact of CYP2A6 genetic variation and enzymatic activity","year":2016,"lang":"en","type":"article","venue":"eScholarship (California Digital Library)","topic":"Geological Studies and Exploration","field":"Earth and Planetary Sciences","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; Centre for Addiction and Mental Health Foundation; Ontario Ministry of Research and Innovation; Campbell Family Mental Health Research Institute; National Institutes of Health; Canadian Institutes of Health Research","keywords":"Cotinine; CYP2A6; Nicotine; Metabolite; Urine; Pharmacokinetics; Metabolism; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009320177,0.0001302871,0.0002739704,0.00008019169,0.00003176739,0.00007857996,0.00005636442,0.0000408625,0.00008137232],"category_scores_gemma":[0.000144152,0.000079525,0.00003176552,0.0002372773,0.0002241766,0.0009131293,0.00004068403,0.00006358605,0.000004817824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002981494,"about_ca_system_score_gemma":0.00001075574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003050952,"about_ca_topic_score_gemma":0.00006285027,"domain_scores_codex":[0.9991826,0.00007537175,0.0002526977,0.0001954305,0.00012661,0.0001673091],"domain_scores_gemma":[0.9993783,0.0002298197,0.0001854836,0.00008073843,0.00001747803,0.0001082191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001342132,0.00004154762,0.9357725,0.00002335556,0.00001841014,7.782385e-7,0.00006675722,0.00002008013,0.001243367,0.00002570972,0.000004329766,0.06264899],"study_design_scores_gemma":[0.0003990895,0.0004353579,0.9960791,0.00003347609,0.00001529826,0.000002895207,0.00003129409,0.0004660496,0.0004012397,0.001972488,0.00006004825,0.0001036044],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979616,0.0003946535,0.0001488512,0.0003648164,0.00001239041,0.0001335904,0.0007816501,0.00001345662,0.0001890164],"genre_scores_gemma":[0.9990986,0.0002934679,0.0005070271,0.00001741827,0.00001780624,0.000001230215,0.0000542284,0.00000410212,0.000006118231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06254538,"threshold_uncertainty_score":0.3242935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01086550907836615,"score_gpt":0.1985776499795747,"score_spread":0.1877121409012086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}