{"id":"W7074120617","doi":"","title":"Disposition kinetics and metabolism of nicotine and cotinine in African American smokers: Impact of CYP2A6 genetic variation and enzymatic activity","year":2016,"lang":"en","type":"article","venue":"eScholarship (California Digital Library)","topic":"Geological Studies and Exploration","field":"Earth and Planetary Sciences","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; Centre for Addiction and Mental Health Foundation; Ontario Ministry of Research and Innovation; Campbell Family Mental Health Research Institute; National Institutes of Health; Canadian Institutes of Health Research","keywords":"Cotinine; CYP2A6; Nicotine; Metabolite; Urine; Pharmacokinetics; Metabolism; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003291574,0.000150369,0.000164402,0.0002182631,0.0002064095,0.000247714,0.00009330177,0.0001980603,0.001270499],"category_scores_gemma":[0.00088061,0.000131604,0.00016658,0.0002629594,0.0001478115,0.0001723663,0.0001107904,0.0002177669,0.000126426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001533697,"about_ca_system_score_gemma":0.0001219644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004482236,"about_ca_topic_score_gemma":0.003396257,"domain_scores_codex":[0.9998477,0.00006312192,0.000006536608,0.00002919395,0.0000315716,0.00002186526],"domain_scores_gemma":[0.9997662,0.00007471345,0.00007439287,0.00002821656,0.00002299135,0.0000334863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001662208,0.0001907096,0.9709442,0.00001513736,0.0001327969,0.0001805674,0.0002056932,0.0001105719,0.01705347,0.00006045499,0.00009509645,0.009349066],"study_design_scores_gemma":[0.00001125947,0.0001696628,0.9979262,0.000002094788,0.0000447356,0.0002550927,0.00005614571,0.0003609493,0.0009687796,0.00003910664,0.0001634332,0.000002499674],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995752,0.000165357,0.00009332056,0.00001728215,9.772322e-7,0.000002093822,0.0000449662,0.000001432955,0.00009940708],"genre_scores_gemma":[0.999542,0.00009370253,0.0001320162,0.00001279337,0.000002749688,0.000002249087,0.00004550732,0.000002115419,0.0001669855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004482236,"threshold_uncertainty_score":0.008912325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01086550907836615,"score_gpt":0.1985776499795747,"score_spread":0.1877121409012086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}