{"id":"W7075736847","doi":"","title":"Multi-omics characterization of improved cognitive functions in Parkinson's disease patients after the combined metabolic activator treatment: a randomized, double-blinded, placebo-controlled phase II trial.","year":2025,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Uppsala Multidisciplinary Center for Advanced Computational Science; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; European Commission","keywords":"Tolerability; Activator (genetics); Disease; Metabolic pathway; Nicotinamide adenine dinucleotide; Cognition; Nicotinamide; Metabolic control analysis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002242045,0.0001888885,0.0009094955,0.0002883986,0.0001470693,0.000009103997,0.00009732616,0.00009149669,0.00001935224],"category_scores_gemma":[0.000441226,0.0001515523,0.0003738105,0.0003690022,0.0002128774,0.0001592168,0.00007745018,0.0001188493,0.0000021045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006992523,"about_ca_system_score_gemma":0.0002492858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009200321,"about_ca_topic_score_gemma":0.00006419919,"domain_scores_codex":[0.9989209,0.0001937905,0.0002990538,0.0002434877,0.0001633526,0.0001794826],"domain_scores_gemma":[0.99857,0.000533631,0.0003193067,0.0002386377,0.0002152819,0.0001231005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9868612,0.003785811,0.004894409,0.00003116872,0.0007573334,0.00000967537,0.0003887838,0.000002215278,0.0006286136,0.00009005241,0.00001874995,0.002532038],"study_design_scores_gemma":[0.9477888,0.0007497235,0.04332688,0.0001452162,0.002471349,1.646614e-7,0.0003433242,0.004053242,0.0006008788,0.000002259,0.0004063191,0.0001118783],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908001,0.0001272567,0.002775838,0.0004586674,0.0001691302,0.00492441,0.0005283876,0.00002649008,0.0001897291],"genre_scores_gemma":[0.9972062,0.0001320444,0.00007244449,0.00008842383,0.00002181907,0.0000666988,0.0004721964,0.00001026087,0.001929928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03907238,"threshold_uncertainty_score":0.6180125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01380181546108237,"score_gpt":0.2497869143857113,"score_spread":0.2359850989246289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}