{"id":"W7080146904","doi":"","title":"Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study","year":2022,"lang":"en","type":"other","venue":"","topic":"Geochemistry and Geologic Mapping","field":"Computer Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Heart, Lung, and Blood Institute; Wageningen University and Research; Instituto de Salud Carlos III; Canadian Institutes of Health Research; National Institutes of Health; Hjartavernd; Kulturministeriet; Paavo Nurmen Säätiö; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Svenska Läkaresällskapet; Göteborgs Läkaresällskap; Eesti Teadusagentuur; Syddansk Universitet; Sydäntutkimussäätiö; Medical Research Council; Servier; Tartu Ülikool; Emil Aaltosen Säätiö; Horizon 2020 Framework Programme; Vetenskapsrådet; Centre for Medical Systems Biology; Novo Nordisk; Juho Vainion Säätiö; U.S. Department of Health and Human Services; Signe ja Ane Gyllenbergin Säätiö; Kempe Foundation; Healthway; Ministry of Agriculture, Forestry and Fisheries; National Institute on Aging; University of Hong Kong; Tampereen Tuberkuloosisäätiö; Kela; Division of Materials Research; European Regional Development Fund; King's College London; Australian Cancer Research Foundation; Academy of Finland; Health Research Council of New Zealand; Nederlandse Zuivel Organisatie; Erasmus Medisch Centrum; Stiftelsen för Strategisk Forskning; Geelong Region Medical Research Foundation; National Science Foundation; Fondation Leducq; National Health and Medical Research Council; Suomen Kulttuurirahasto; Jewish General Hospital; Forskningsrådet för Arbetsliv och Socialvetenskap; National Institute for Health and Care Research; Amgen; Steirische Wirtschaftsförderungsgesellschaft; World Anti-Doping Agency; Austrian Federal Ministry of Economy, Family and Youth; Wellcome Trust; Yrjö Jahnssonin Säätiö; Chinese University of Hong Kong; Eli Lilly and Company; Foundation for Cardiovascular Research; Umeå Universitet; European Commission; Sanofi; Pfizer; National Center for Research Resources; Diabetesliitto; National and Kapodistrian University of Athens; Bundesministerium für Verkehr, Innovation und Technologie; Ministerie van Economische Zaken, Landbouw en Innovatie; ZonMw","keywords":"Genome-wide association study; Bone mineral; Odds ratio; Confidence interval; Single-nucleotide polymorphism; Fracture (geology); Osteoporosis; Genotyping; Bone density","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02666987,0.001538,0.002460556,0.001076644,0.0009792295,0.001140637,0.002033499,0.002024165,0.00436055],"category_scores_gemma":[0.05552059,0.001177732,0.004414696,0.002561401,0.0009237987,0.0009053737,0.001120209,0.001462946,0.0006495119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006093131,"about_ca_system_score_gemma":0.001110257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003503332,"about_ca_topic_score_gemma":0.002755861,"domain_scores_codex":[0.967985,0.02340115,0.001965587,0.004120127,0.001869534,0.0006586588],"domain_scores_gemma":[0.984724,0.007888057,0.001610836,0.004654957,0.0008153525,0.0003068209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05733263,0.0008364594,0.774168,0.002925857,0.09398434,0.002338593,0.000843467,0.005030991,0.004689904,0.008583833,0.01402565,0.0352402],"study_design_scores_gemma":[0.05037424,0.008652502,0.7469339,0.0008582344,0.08529955,0.005955308,0.0004278937,0.04353147,0.003905352,0.02860642,0.0250408,0.0004143686],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7919137,0.01137711,0.1692869,0.00231662,0.0009599295,0.01068264,0.008857102,0.000669645,0.003936363],"genre_scores_gemma":[0.9621638,0.0006869453,0.02476051,0.0007485796,0.0001357381,0.007687537,0.00252841,0.00009917975,0.00118927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02666987,"threshold_uncertainty_score":0.1410455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01401488902463284,"score_gpt":0.2917319061120144,"score_spread":0.2777170170873816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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