{"id":"W7080182413","doi":"","title":"Combined effects of genotype and childhood adversity shape variability of DNA methylation across age","year":2022,"lang":"en","type":"other","venue":"","topic":"Geochemistry and Geologic Mapping","field":"Computer Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Simon Fraser University","funders":"National Institute of Mental Health; Laureate Institute for Brain Research, University of Tulsa; Greenwich Biosciences; Sunovion; H. Lundbeck A/S; Allergan; Emil Aaltosen Säätiö; Signe ja Ane Gyllenbergin Säätiö; British Heart Foundation; Clinical Science Research and Development; Vistagen Therapeutics; ACADIA Pharmaceuticals; Jazz Pharmaceuticals; Wellcome Trust; Samfundet Folkhälsan; Helsingin Yliopisto; American Foundation for Suicide Prevention; Celgene; National Institutes of Health; Novo Nordisk; OPKO Health; BrainsWay; Folkhälsanin Tutkimussäätiö; Sage Therapeutics; Finska Läkaresällskapet; Bundesministerium für Bildung und Forschung; American Psychiatric Publishing","keywords":"dNaM; Epigenetics; Genotype; DNA methylation; Gene–environment interaction; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006031517,0.0002847782,0.0003474922,0.0004887426,0.0002213535,0.0005143826,0.0002996746,0.0003156324,0.001976399],"category_scores_gemma":[0.001809453,0.0002750664,0.0005102783,0.0005112533,0.0003185397,0.0002161816,0.0004867556,0.0003563792,0.0002805783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002120149,"about_ca_system_score_gemma":0.0002208595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00720508,"about_ca_topic_score_gemma":0.01150629,"domain_scores_codex":[0.9994887,0.0001473033,0.00002154577,0.0002434277,0.00004579842,0.00005318256],"domain_scores_gemma":[0.9989631,0.000357092,0.0002789099,0.0002321059,0.00008876363,0.00008006205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003401356,0.00001570483,0.9675712,0.0000424829,0.000663953,0.0001077333,0.0004108365,0.0007116129,0.0196176,0.0002135066,0.0002516382,0.0100535],"study_design_scores_gemma":[0.000001473609,0.00004780782,0.998067,0.000006429703,0.00007366578,0.0001090998,0.00008164509,0.0003786755,0.0007473432,0.0001855368,0.0002966408,0.00000474864],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946797,0.0005560574,0.002447326,0.00004877545,0.000008323752,0.000006247445,0.001531064,0.00003550476,0.0006868949],"genre_scores_gemma":[0.9978325,0.000184024,0.0008875128,0.00003412703,0.000003992951,0.000009708318,0.0006322585,0.000023199,0.0003926932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00720508,"threshold_uncertainty_score":0.01432627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005709903146988144,"score_gpt":0.2101794696156535,"score_spread":0.2044695664686654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}