{"id":"W7082074072","doi":"10.2139/ssrn.5442015","title":"Copper ionophores drive divergent responses to immune checkpoint inhibition across colorectal tumor models","year":2025,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Geochemistry and Geologic Mapping","field":"Computer Science","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Immune system; Immunogenic cell death; Immune checkpoint; Calreticulin; Clioquinol; Programmed cell death; In vitro; Copper; Immunotherapy; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001673033,0.0003785446,0.0003803119,0.0003042923,0.0002184492,0.0004523812,0.0004104886,0.0004055964,0.002119535],"category_scores_gemma":[0.0002397529,0.0001726078,0.0002990673,0.0002394895,0.0003857551,0.0002047914,0.0003340651,0.0008984845,0.0002628042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001013242,"about_ca_system_score_gemma":0.0004201993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003325886,"about_ca_topic_score_gemma":0.00490226,"domain_scores_codex":[0.9997929,0.00002979646,0.00001226687,0.00005044688,0.00003923123,0.00007538753],"domain_scores_gemma":[0.9998332,0.00002496614,0.0000470546,0.0000186504,0.00002338734,0.00005265103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001965478,0.0002829257,0.0004996646,0.00009021556,0.00002778015,0.00006290095,0.00004810946,0.001841127,0.9904445,0.0006051327,0.0005793473,0.00355283],"study_design_scores_gemma":[0.0001620794,0.00277001,0.001494285,0.00001167407,0.00008115984,0.00009164422,0.0001089409,0.005697661,0.9860773,0.0002717155,0.003217204,0.0000163059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995873,0.0004328738,0.001513363,0.0001881444,0.00005829297,0.00003188393,0.0004353416,0.0001243255,0.001342693],"genre_scores_gemma":[0.995823,0.0003460615,0.0007739424,0.00005136343,0.000005790229,0.00004798349,0.0003006674,0.00003480365,0.002616422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003325886,"threshold_uncertainty_score":0.007351696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01325565002304098,"score_gpt":0.2582732118189379,"score_spread":0.2450175617958969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}