{"id":"W7083587596","doi":"10.1016/j.brci.2025.100030","title":"Integrated analysis of blood donor metabolic phenotypes and genetic traits on red blood cell transfusion effectiveness","year":2025,"lang":"en","type":"article","venue":"Blood Red Cells & Iron","topic":"Diverse Scientific and Economic Studies","field":"Economics, Econometrics and Finance","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Red blood cell; Phenotype; Transfusion medicine; Hemoglobin; Blood donor; Population; Blood transfusion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004140208,0.0002792394,0.001024113,0.0008735724,0.0001447703,0.00005653938,0.0002461574,0.0001454089,0.0005692735],"category_scores_gemma":[0.0000275732,0.0002866151,0.0002976715,0.001057882,0.0001323532,0.00007771773,0.0000667132,0.0001361643,0.00006569197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001618586,"about_ca_system_score_gemma":0.00002271319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003333198,"about_ca_topic_score_gemma":0.00005468731,"domain_scores_codex":[0.9980614,0.00006013209,0.0006840687,0.0008194925,0.00005000276,0.0003249562],"domain_scores_gemma":[0.9991092,0.0001276302,0.0002849664,0.0003589445,0.00004155146,0.00007767264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00191021,0.01700793,0.2074203,0.003072432,0.05212842,0.0001066247,0.009152244,0.0168458,0.6211208,0.04334496,0.005039515,0.02285078],"study_design_scores_gemma":[0.01531911,0.0008473354,0.4496489,0.000230662,0.02339121,0.000003216142,0.0008400795,0.002465446,0.4850316,0.001977065,0.01866481,0.001580575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9577841,0.006343137,0.00008243452,0.00003809106,0.0005094229,0.0003640535,0.0004336897,0.00003195904,0.03441313],"genre_scores_gemma":[0.9893402,0.003245448,0.0004382199,0.00003904501,0.00002276859,0.00002824096,0.0000226202,0.00001864153,0.006844808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2422285,"threshold_uncertainty_score":0.9999586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009826179479854966,"score_gpt":0.1836814704692969,"score_spread":0.1738552909894419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}