{"id":"W7084132068","doi":"10.1016/j.addicn.2025.100240","title":"Sex-specific transcriptional signatures of oxycodone persist during withdrawal and abstinence in the suprachiasmatic nucleus of heterogeneous stock rats","year":2025,"lang":"en","type":"article","venue":"Addiction Neuroscience","topic":"Geophysical Methods and Applications","field":"Engineering","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; Fonds de Recherche du Québec - Santé; National Institutes of Health; Australasian Association of Philosophy","keywords":"Suprachiasmatic nucleus; Opioid; Circadian rhythm; Neurotransmitter; Oxycodone; Neurotransmitter systems; Central nucleus of the amygdala; Hypothalamus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007809658,0.0001929446,0.0002815741,0.0004025092,0.0001574322,0.0002398357,0.0001020172,0.0001496592,0.001216787],"category_scores_gemma":[0.0001314701,0.0001528387,0.0003236345,0.0001928942,0.0002542713,0.0001383563,0.0002499109,0.0004281733,0.0001727125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001863226,"about_ca_system_score_gemma":0.0002148494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002225786,"about_ca_topic_score_gemma":0.004970471,"domain_scores_codex":[0.9998748,0.000006825979,0.000006333822,0.00005153981,0.00002863809,0.00003187053],"domain_scores_gemma":[0.9998425,0.00001156929,0.00006050428,0.00001209082,0.00002933888,0.00004386288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008076038,0.0000577132,0.02462731,0.0000521758,0.00006165355,0.0001271851,0.0001465853,0.00006184299,0.9679396,0.00009941714,0.0001660599,0.005852905],"study_design_scores_gemma":[0.00003607531,0.0006204156,0.8969461,0.00002313172,0.0001323368,0.0003820147,0.0005297787,0.000666945,0.09873299,0.0001963824,0.001696009,0.00003770682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972258,0.0005810495,0.0006429598,0.0000504659,0.0000169355,0.000006477456,0.001154523,0.0000215697,0.0003002531],"genre_scores_gemma":[0.9934108,0.0006124199,0.0007518778,0.0001298779,0.00001178671,0.00006111791,0.001700478,0.00004217749,0.003279459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002225786,"threshold_uncertainty_score":0.004425585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01198513845232367,"score_gpt":0.2335840254337498,"score_spread":0.2215988869814261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}