{"id":"W7084132068","doi":"10.1016/j.addicn.2025.100240","title":"Sex-specific transcriptional signatures of oxycodone persist during withdrawal and abstinence in the suprachiasmatic nucleus of heterogeneous stock rats","year":2025,"lang":"en","type":"article","venue":"Addiction Neuroscience","topic":"Geophysical Methods and Applications","field":"Engineering","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; Fonds de Recherche du Québec - Santé; National Institutes of Health; Australasian Association of Philosophy","keywords":"Suprachiasmatic nucleus; Opioid; Circadian rhythm; Neurotransmitter; Oxycodone; Neurotransmitter systems; Central nucleus of the amygdala; Hypothalamus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009227499,0.00006615152,0.00009451014,0.00006625672,0.00007663068,0.00001480184,0.000145418,0.000020572,0.00000338881],"category_scores_gemma":[0.00002036567,0.00005457683,0.00002652398,0.0004029948,0.00014469,0.00006705592,0.00001240343,0.0001110581,2.832519e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007481532,"about_ca_system_score_gemma":0.000006827268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005057298,"about_ca_topic_score_gemma":0.000002324925,"domain_scores_codex":[0.9994325,0.0000353057,0.0001667957,0.0001395611,0.0001331278,0.00009271198],"domain_scores_gemma":[0.9997096,0.00009742598,0.00002797478,0.0001307513,0.00001664395,0.00001757223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000005015072,0.0000406247,0.0002097637,0.00003712039,0.000001611295,7.401094e-7,0.0002534107,0.02321982,0.973243,0.001426081,0.00001162489,0.00155118],"study_design_scores_gemma":[0.0003754809,0.00009372521,0.8002812,0.00008807365,0.00001979956,0.00002340422,0.0001535585,0.09089046,0.1064569,0.000681809,0.0007752762,0.0001603179],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958555,0.0001739612,0.003406266,0.0000712221,0.00009937061,0.0001339481,0.00001994818,0.00002295288,0.0002168191],"genre_scores_gemma":[0.9992852,0.00005715835,0.000575734,0.00002890032,0.00000853412,0.000019432,6.541767e-7,0.000003747429,0.00002068282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8667861,"threshold_uncertainty_score":0.2225579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01198513845232367,"score_gpt":0.2335840254337498,"score_spread":0.2215988869814261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}