{"id":"W7084497549","doi":"10.1111/cge.14784/v2/response1","title":"Author response for \"<i>PMS2</i> c.2117del (p.Lys706Serfs*19) is the Most Frequent Cancer-Associated Founder Pathogenic Variant in the French-Canadian Population of Quebec, Canada\"","year":2025,"lang":"en","type":"peer-review","venue":"","topic":"Geochemistry and Geologic Mapping","field":"Computer Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Population; Founder effect; Genetic genealogy; Allele frequency","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002992345,0.0009833004,0.002192194,0.001761237,0.002904487,0.002947921,0.001922227,0.006447901,0.4143769],"category_scores_gemma":[0.04202433,0.0006845659,0.00104437,0.00143532,0.001324368,0.001520567,0.001785006,0.005280523,0.1872519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005957007,"about_ca_system_score_gemma":0.01157182,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1153228,"about_ca_topic_score_gemma":0.1910612,"domain_scores_codex":[0.9962846,0.0005301326,0.0004256255,0.0003500787,0.001697688,0.0007118165],"domain_scores_gemma":[0.9600084,0.003537859,0.00102357,0.001028682,0.02977202,0.004629418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001928911,0.00000177668,0.00004589466,0.00003948735,0.000001622203,0.00001388908,0.000006960617,0.000003982584,0.00001314913,0.00002975569,0.9989181,0.000906295],"study_design_scores_gemma":[0.0001367832,0.00001883916,0.002417807,0.0002933902,0.00001274555,0.0001282806,0.0002229597,0.00006437475,0.0001531924,0.0002307194,0.9962774,0.00004351666],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.001052995,0.002047098,0.001026484,0.5301968,0.3667836,0.001277289,0.04607312,0.002446554,0.04909613],"genre_scores_gemma":[0.01024278,0.003047711,0.001600332,0.1981744,0.05231854,0.001348587,0.02029465,0.001713507,0.7112595],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.8846772,"threshold_uncertainty_score":0.8353202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03112913377002226,"score_gpt":0.277068884648986,"score_spread":0.2459397508789638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}