{"id":"W7084595002","doi":"10.6084/m9.figshare.c.8070727.v1","title":"Comprehensive comparison of enzymatic and bisulfite DNA methylation analysis in clinically relevant samples","year":2025,"lang":"en","type":"other","venue":"Figshare","topic":"Education, sociology, and vocational training","field":"Social Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada); Newborn Screening Ontario","funders":"","keywords":"Bisulfite; Bisulfite sequencing; DNA methylation; Methylation; DNA; Illumina Methylation Assay","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004083343,0.0003961327,0.0004035062,0.0006919549,0.0002999507,0.0007227882,0.0004407453,0.0005614014,0.001165164],"category_scores_gemma":[0.004701479,0.0002079083,0.0003358558,0.0005161655,0.0004763231,0.0001965624,0.0005767643,0.0004603665,0.0003308506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003546884,"about_ca_system_score_gemma":0.0005657997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008796674,"about_ca_topic_score_gemma":0.001849761,"domain_scores_codex":[0.9962573,0.001328257,0.0002815522,0.0008531893,0.001148022,0.0001317144],"domain_scores_gemma":[0.9981475,0.0006965368,0.0003265575,0.0002856187,0.0004723404,0.00007143622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003180191,0.0004114577,0.105687,0.0007177846,0.0009903316,0.0001116174,0.0005477901,0.005315215,0.8032681,0.0009131925,0.001647942,0.07720939],"study_design_scores_gemma":[0.000277211,0.004156418,0.2109791,0.0000866433,0.0008509431,0.000853441,0.0002136553,0.01125838,0.7519939,0.001479821,0.01777861,0.00007190542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9430497,0.003264059,0.04405724,0.0002707852,0.00006930056,0.0005599148,0.005465095,0.0004149436,0.002848961],"genre_scores_gemma":[0.956259,0.0006342703,0.03272342,0.0003955732,0.00003946984,0.0007043376,0.007965936,0.00009708037,0.001180969],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.004083343,"threshold_uncertainty_score":0.02159506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3575272077091379,"score_gpt":0.520316734282838,"score_spread":0.1627895265737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}