{"id":"W7084606496","doi":"10.1111/cge.14784/v1/decision1","title":"Decision letter for \"<i>PMS2</i> c.2117del (p.Lys706Serfs*19) is the Most Frequent Cancer-Associated Founder Pathogenic Variant in the French-Canadian Population of Quebec, Canada\"","year":2025,"lang":"en","type":"peer-review","venue":"","topic":"Lymphadenopathy Diagnosis and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Population; Founder effect; Mutation","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003143742,0.0005783471,0.001628393,0.00163284,0.00306606,0.003757137,0.002518879,0.01738856,0.1382806],"category_scores_gemma":[0.03887571,0.000587843,0.001513595,0.0008982286,0.001798628,0.002032651,0.001404992,0.008749465,0.09234466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00429463,"about_ca_system_score_gemma":0.01225834,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03714489,"about_ca_topic_score_gemma":0.07825121,"domain_scores_codex":[0.9962782,0.0004871048,0.000338467,0.0003134081,0.002040571,0.000542302],"domain_scores_gemma":[0.9788534,0.003264922,0.000653459,0.0007567783,0.01190647,0.004565078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001367718,0.000004904344,0.00003536456,0.0000166134,0.000002072746,0.00005291148,0.000004304995,0.000006055837,0.00001452939,0.0001586219,0.9980843,0.001606734],"study_design_scores_gemma":[0.0001020309,0.00001592728,0.000681819,0.0001769957,0.00000985381,0.0002020162,0.00005607664,0.0001318628,0.00008486034,0.0007513289,0.9977657,0.00002173366],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.0006155822,0.001202427,0.000505059,0.655957,0.2882736,0.0005429565,0.002765243,0.0006893641,0.04944873],"genre_scores_gemma":[0.007902252,0.002266388,0.001593555,0.4464419,0.1015184,0.0004374498,0.002565908,0.0005532236,0.4367209],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.9628551,"threshold_uncertainty_score":0.4625947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02144354935551356,"score_gpt":0.2877651380732567,"score_spread":0.2663215887177431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}