{"id":"W7084606496","doi":"10.1111/cge.14784/v1/decision1","title":"Decision letter for \"<i>PMS2</i> c.2117del (p.Lys706Serfs*19) is the Most Frequent Cancer-Associated Founder Pathogenic Variant in the French-Canadian Population of Quebec, Canada\"","year":2025,"lang":"en","type":"peer-review","venue":"","topic":"Lymphadenopathy Diagnosis and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Population; Founder effect; Mutation","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001634667,0.0007536587,0.001886997,0.0005580855,0.0003750751,0.0001038365,0.0009697879,0.0005929616,0.001604841],"category_scores_gemma":[0.001421504,0.0004419582,0.0008333896,0.001728542,0.0000789458,0.00009305424,0.00009631553,0.0004663383,0.000006014787],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.004852808,"about_ca_system_score_gemma":0.009976641,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9951539,"about_ca_topic_score_gemma":0.9999125,"domain_scores_codex":[0.9942291,0.000405718,0.001830548,0.0009665563,0.001663696,0.0009044232],"domain_scores_gemma":[0.9951375,0.001281257,0.0008528133,0.001465249,0.0009304968,0.0003326801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001311892,0.0001573023,0.0008914041,0.0008038403,0.0006694278,0.00009688803,0.0001316183,0.00004145575,0.00004599027,0.0002559007,0.9815974,0.01529563],"study_design_scores_gemma":[0.001538229,0.00006625917,0.04201618,0.006176224,0.004176488,0.00001468936,0.00004022702,0.0008329657,0.00001207164,0.000355143,0.944213,0.0005584636],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.008261184,0.133959,0.00044897,0.8328274,0.004212208,0.007732547,0.008281369,0.00005382283,0.004223505],"genre_scores_gemma":[0.2207576,0.04518196,0.0004175037,0.4613023,0.001861031,0.003298571,0.01676191,0.0002552005,0.250164],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.3715252,"threshold_uncertainty_score":0.9998032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02144354935551356,"score_gpt":0.2877651380732567,"score_spread":0.2663215887177431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}