{"id":"W7086953518","doi":"10.24433/co.2026091.v1","title":"Epigenomic Rewiring of Transcriptional Regulators by Chromatin Variants Drives Tumor Evolution in Triple Negative Breast Cancer","year":2025,"lang":"en","type":"other","venue":"Code Ocean","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Epigenomics; Chromatin; Reprogramming; Epigenome; Transcription factor; Chromatin remodeling; Epigenetics; Regulation of gene expression; Transcriptome; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001090656,0.0002192406,0.0002977833,0.0001186621,0.00002903544,0.000009915135,0.0002062899,0.0002670636,0.0002085483],"category_scores_gemma":[0.000008960764,0.0002269109,0.00009236709,0.0001039303,0.00009177344,0.000003151792,0.00005194952,0.0001271849,0.000002740357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007599359,"about_ca_system_score_gemma":0.0002607767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003936142,"about_ca_topic_score_gemma":0.0005466949,"domain_scores_codex":[0.9990188,0.00003920924,0.0003541961,0.000280747,0.00009228959,0.0002147214],"domain_scores_gemma":[0.9994018,0.000005780798,0.0002644293,0.0002473439,0.00003384937,0.00004681164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003107269,0.0002176836,0.003252614,0.000747152,0.000634198,0.000003310969,0.0003345835,0.000672829,0.1292795,0.001681792,0.8583766,0.004489044],"study_design_scores_gemma":[0.03143413,0.001185748,0.2673613,0.01528836,0.001182021,0.0001322036,0.001894847,0.02662479,0.07755949,0.01029895,0.5579576,0.009080559],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.2957894,0.07856065,0.05342316,0.001323645,0.006572463,0.007086283,0.05149006,0.0002886326,0.5054657],"genre_scores_gemma":[0.822796,0.00104518,0.00112584,0.0001458653,0.0004782057,0.00002493567,0.0008822755,0.0002154726,0.1732862],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5270066,"threshold_uncertainty_score":0.9253156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003984961281437087,"score_gpt":0.2151839667290724,"score_spread":0.2111990054476353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}