{"id":"W7092183938","doi":"10.1016/b978-0-443-21848-4.00002-9","title":"Characterizing enzyme kinetics by 2D-ITC","year":2025,"lang":"en","type":"book-chapter","venue":"Elsevier eBooks","topic":"thermodynamics and calorimetric analyses","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; University of Alberta","funders":"","keywords":"Isothermal titration calorimetry; Substrate (aquarium); Yield (engineering); Kinetics; Catalysis; Calorimetry; Enzyme catalysis; Product inhibition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00008382477,0.0006052295,0.0007459305,0.0001748234,0.00009470327,0.00009109872,0.0005473089,0.0006769632,0.002163432],"category_scores_gemma":[0.00002424874,0.0006109774,0.0004372637,0.00002536151,0.0001034268,0.00002239973,0.0002385169,0.0007318711,0.0001332878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001820592,"about_ca_system_score_gemma":0.00009204328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002042037,"about_ca_topic_score_gemma":0.000004227515,"domain_scores_codex":[0.9980153,0.000007816409,0.0005869763,0.0006186877,0.0003855894,0.0003856086],"domain_scores_gemma":[0.9984707,0.00009560031,0.0003682676,0.0008117589,0.0001015558,0.0001521369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001221278,0.00001710021,0.000001939864,0.0002255591,0.000353496,0.00002711486,0.0000341415,1.05992e-7,0.02268449,0.003568379,0.001298157,0.9717773],"study_design_scores_gemma":[0.0001940009,0.00001612015,8.796609e-7,0.0004573327,0.0003686312,0.000005301958,0.000005551655,0.00003955531,0.005083109,0.001811551,0.9914206,0.0005974179],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.0001067429,0.004287797,0.00003062047,0.00004637313,0.0002554445,0.00009893593,0.000451121,0.0001294899,0.9945935],"genre_scores_gemma":[0.004288793,0.0004970433,0.00007133054,0.0004032758,0.0004678205,0.00001745307,0.0003823756,0.000123455,0.9937484],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.9901224,"threshold_uncertainty_score":0.9996341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01052435170652354,"score_gpt":0.2266197498762161,"score_spread":0.2160953981696926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}