{"id":"W7093122371","doi":"","title":"P178 | ARGININE DEPRIVATION INDUCES CANCER DORMANCY AND GENOMIC INSTABILITY: THE SEED AND SOIL OF MULTIPLE MYELOMA RECURRENCE","year":2025,"lang":"en","type":"article","venue":"DOAJ (DOAJ: Directory of Open Access Journals)","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surgical Specialties (Canada)","funders":"","keywords":"Multiple myeloma; Histone; Arginine; ATF4; Chromatin; Epigenetics; Integrated stress response; CHOP; DNA damage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001892677,0.000279118,0.0004534696,0.0003688218,0.0002317856,0.0006622596,0.0002470152,0.0004469978,0.001423255],"category_scores_gemma":[0.0002256322,0.000160925,0.0003131432,0.0004471108,0.0003188873,0.0003641309,0.0004574923,0.0007696291,0.0003888888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003034394,"about_ca_system_score_gemma":0.0002313747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004142825,"about_ca_topic_score_gemma":0.0005426939,"domain_scores_codex":[0.9998293,0.0000151385,0.000008464081,0.00005741732,0.00006605531,0.0000236688],"domain_scores_gemma":[0.9998147,0.00002386851,0.00007347042,0.00002560307,0.00002497363,0.0000373711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003153019,0.00002421093,0.005844016,0.0001127414,0.0000262184,0.0006419779,0.00005307964,0.00009722867,0.9850669,0.000185175,0.0002155461,0.007417638],"study_design_scores_gemma":[0.00004793629,0.001008971,0.209858,0.00004122007,0.0001072243,0.006888392,0.0003411167,0.003066736,0.7553603,0.001256514,0.02198673,0.00003682027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816306,0.006942227,0.006052433,0.0008970232,0.00008736665,0.00005918118,0.001845921,0.0003662097,0.002118975],"genre_scores_gemma":[0.9923119,0.001923522,0.002225125,0.0002288947,0.00003353896,0.00002909331,0.001133673,0.00004916273,0.002064997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001423255,"threshold_uncertainty_score":0.004761338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1211273787856284,"score_gpt":0.5066075921654631,"score_spread":0.3854802133798347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}