{"id":"W7094949757","doi":"10.6084/m9.figshare.30415822.v2","title":"<b>RORγt: A Drug Target in Organ Transplantation — Identification of Novel Modulators of RORγt by Rational Drug Design and Molecular Docking</b>","year":2025,"lang":"","type":"other","venue":"Figshare","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Drug discovery; Cytokine; PubChem; Drug; Flow cytometry; Peripheral blood mononuclear cell; RAR-related orphan receptor gamma; Transplantation","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004352468,0.000957143,0.0008518939,0.0003233841,0.0002516804,0.00108508,0.0005303632,0.0006061179,0.005556253],"category_scores_gemma":[0.0003759783,0.0002272922,0.0009804902,0.0004503978,0.0002868309,0.0005018724,0.0005161581,0.0008126574,0.001698811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004774905,"about_ca_system_score_gemma":0.001021902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001457247,"about_ca_topic_score_gemma":0.001610179,"domain_scores_codex":[0.9998206,0.00004775299,0.000009294973,0.00003424914,0.00005815134,0.00002986004],"domain_scores_gemma":[0.9999236,0.00001999229,0.00001581492,0.00001050345,0.00001773073,0.0000123075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001319069,0.000691043,0.003570101,0.002411034,0.0004846434,0.0007051426,0.00009856274,0.4817098,0.2198098,0.02519283,0.02047281,0.2435351],"study_design_scores_gemma":[0.0007270614,0.002046904,0.001307359,0.0002389651,0.0003739116,0.0008946219,0.0001020918,0.6382248,0.231379,0.01069076,0.1138793,0.0001352991],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.4034259,0.03352121,0.4923492,0.006785246,0.001158359,0.000758428,0.00662112,0.007522493,0.04785807],"genre_scores_gemma":[0.7245523,0.02774863,0.2251244,0.001146665,0.0001898634,0.0004274657,0.005970008,0.0005426244,0.01429806],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.005556253,"threshold_uncertainty_score":0.01858753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01380366634832596,"score_gpt":0.2502310437890892,"score_spread":0.2364273774407633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}