{"id":"W70976452","doi":"10.1182/blood.v122.21.70.70","title":"A Phase 1/2 Study Of Blinatumomab In Pediatric Patients With Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Blinatumomab; Medicine; Refractory (planetary science); Cytokine release syndrome; Internal medicine; Acute lymphocytic leukemia; Hematopoietic stem cell transplantation; Bone marrow; Toxicity; Phases of clinical research; Clinical endpoint; Gastroenterology; Leukemia; Oncology; Transplantation; Clinical trial; Lymphoblastic Leukemia; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00224617,0.001665837,0.001927116,0.0004737251,0.0004577073,0.000802781,0.0009157927,0.000913505,0.002648854],"category_scores_gemma":[0.0007270949,0.0006480094,0.0009981019,0.0005174475,0.00083637,0.0006755215,0.0003541035,0.003052979,0.0007223822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009412209,"about_ca_system_score_gemma":0.002229672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001143022,"about_ca_topic_score_gemma":0.002294294,"domain_scores_codex":[0.9992099,0.0004696572,0.00003541957,0.00009870017,0.000060636,0.0001257291],"domain_scores_gemma":[0.9994161,0.0000877477,0.0001106625,0.00005761911,0.00005045813,0.0002773078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4372925,0.2087144,0.02377491,0.001536889,0.001394585,0.001463004,0.0009625875,0.004151225,0.1542275,0.0008478554,0.006978017,0.1586565],"study_design_scores_gemma":[0.3174255,0.649312,0.01605991,0.00004287337,0.0003801006,0.0008136731,0.0001262305,0.000912218,0.009716212,0.0002040848,0.004978599,0.00002855527],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917228,0.001584412,0.0007556642,0.0004619065,0.00007539491,0.003552025,0.0009629547,0.00007866538,0.0008061029],"genre_scores_gemma":[0.9806112,0.003008799,0.004927205,0.0008993175,0.0002091007,0.005890999,0.002477405,0.00004673977,0.001929118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002648854,"threshold_uncertainty_score":0.01187903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00788388270475319,"score_gpt":0.2522303062107417,"score_spread":0.2443464235059885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}