{"id":"W7097822067","doi":"","title":"A BRIEF REVIEW OF SCIENTIFIC AND REGULATORY CONSIDERATIONS","year":2016,"lang":"en","type":"article","venue":"","topic":"Chemistry and Stereochemistry Studies","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Enantiomer; Key (lock); Sequence (biology); Drug; Drug development; Molecule","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005136274,0.001279198,0.001599885,0.006021238,0.001046138,0.003616621,0.002262313,0.006282554,0.0151884],"category_scores_gemma":[0.01104465,0.0005429361,0.00109595,0.005707371,0.00167808,0.004538921,0.001482643,0.005192887,0.009019342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003079967,"about_ca_system_score_gemma":0.007026602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00368484,"about_ca_topic_score_gemma":0.004602281,"domain_scores_codex":[0.9972025,0.000601105,0.0005238192,0.0003116544,0.001190923,0.0001700607],"domain_scores_gemma":[0.9935287,0.003190736,0.0008117388,0.0001568215,0.001919473,0.000392514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005996691,0.0001113443,0.0003138265,0.008793169,0.00003562337,0.0007243148,0.000162217,0.0005019053,0.0004110943,0.02770806,0.4534902,0.5076883],"study_design_scores_gemma":[0.000005930124,0.00002204262,0.0002027137,0.00346957,0.00001333015,0.0004831121,0.00004934167,0.0000486887,0.00005835684,0.002778338,0.9928558,0.00001268392],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002350191,0.9465723,0.001229968,0.02553512,0.008845231,0.00006168786,0.0003007658,0.00007546465,0.01714443],"genre_scores_gemma":[0.001859665,0.9612185,0.001979059,0.01776657,0.009883246,0.0001110956,0.000399971,0.00003224462,0.006749553],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0151884,"threshold_uncertainty_score":0.05081022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02143398844601315,"score_gpt":0.2487541902068288,"score_spread":0.2273202017608156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}