{"id":"W7100110129","doi":"","title":"Predicting Tipranavir and Darunavir Resistance Using Genotypic, Phenotypic, and Virtual Phenotypic Resistance Patterns: an Independent Cohort Analysis of Clinical Isolates","year":2010,"lang":"en","type":"article","venue":"","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Darunavir; Genotype; Phenotype; Multivariate analysis; Drug resistance; Cohort","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00302991,0.0006395491,0.0005064945,0.0008505203,0.0007142741,0.001022585,0.000524148,0.0005013728,0.0006830394],"category_scores_gemma":[0.006273513,0.0004272485,0.001055316,0.0004284919,0.0004843395,0.0005170911,0.0006280447,0.00104756,0.0002767385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005443434,"about_ca_system_score_gemma":0.0008641902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007954782,"about_ca_topic_score_gemma":0.007939876,"domain_scores_codex":[0.9986451,0.0004782345,0.0000701792,0.0003311749,0.0003066866,0.0001685788],"domain_scores_gemma":[0.996564,0.001141417,0.0003477966,0.00092268,0.0006248353,0.0003992087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001567564,0.0004873648,0.9832646,0.000006262917,0.0002499901,0.0001479582,0.0002091718,0.00105043,0.004107506,0.00004000151,0.0002458148,0.008623253],"study_design_scores_gemma":[0.0001590434,0.002173168,0.9554704,0.00001040189,0.0002656186,0.001111359,0.0004228555,0.03428815,0.005237967,0.0001516762,0.0006502593,0.00005916959],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994272,0.00001741505,0.000357122,0.00001019607,0.000003127172,0.00001416193,0.00009733905,0.000003894784,0.00006964188],"genre_scores_gemma":[0.9985483,0.00002496749,0.0006472301,0.00001121676,0.000006497747,0.00001613548,0.0006071337,0.000006113822,0.000132281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007954782,"threshold_uncertainty_score":0.01602387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02382732672056294,"score_gpt":0.322189376355792,"score_spread":0.2983620496352291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}