{"id":"W7102401615","doi":"10.6084/m9.figshare.30473319.v1","title":"Additional file 1 of POINTER: study protocol for a phase 2b, randomised, placebo-controlled, double-blind, parallel group dose-finding clinical study to evaluate the efficacy of RMC-035 on renal function and safety, in participants at high risk for kidney injury, following open-chest cardiac surgery","year":2025,"lang":"","type":"article","venue":"Open MIND","topic":"Acute Kidney Injury Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"Clinical study; Protocol (science); Renal function; Clinical trial; Function (biology); Phase (matter)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.005956665,0.001810833,0.003480827,0.001053837,0.001605156,0.00145383,0.001849507,0.002582018,0.7915229],"category_scores_gemma":[0.02876006,0.001602234,0.001481691,0.001918165,0.0008215702,0.001792165,0.0007034008,0.002531554,0.0743897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001398562,"about_ca_system_score_gemma":0.004045271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001965905,"about_ca_topic_score_gemma":0.004454328,"domain_scores_codex":[0.9981148,0.0008992237,0.0003220697,0.000251655,0.0002146918,0.0001975801],"domain_scores_gemma":[0.9796199,0.01369892,0.002013141,0.001443487,0.002285094,0.0009393248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1406753,0.005031729,0.0007345956,0.04229137,0.0008636328,0.0001134276,0.0002466595,0.0009813242,0.001188207,0.004940718,0.7552263,0.04770673],"study_design_scores_gemma":[0.7611942,0.01024626,0.005549251,0.005129962,0.001037005,0.0001985766,0.0001045272,0.00111172,0.001093054,0.008199083,0.2059878,0.0001483894],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"protocol","genre_scores_codex":[0.004302192,0.001131419,0.006167876,0.001874996,0.001111998,0.1412871,0.8260151,0.001625115,0.01648437],"genre_scores_gemma":[0.03893229,0.001856058,0.03446442,0.005315038,0.001087023,0.7459274,0.1241307,0.0007821597,0.04750494],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.7915229,"threshold_uncertainty_score":0.2973672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1818653995140243,"score_gpt":0.4958107444448852,"score_spread":0.313945344930861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}