{"id":"W7102416413","doi":"10.6084/m9.figshare.30473319","title":"Additional file 1 of POINTER: study protocol for a phase 2b, randomised, placebo-controlled, double-blind, parallel group dose-finding clinical study to evaluate the efficacy of RMC-035 on renal function and safety, in participants at high risk for kidney injury, following open-chest cardiac surgery","year":2025,"lang":"","type":"article","venue":"Figshare","topic":"Acute Kidney Injury Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"Clinical study; Protocol (science); Renal function; Clinical trial; Function (biology); Phase (matter)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.005864858,0.001752507,0.003471047,0.001124868,0.001544825,0.001570656,0.001852307,0.002536425,0.8286208],"category_scores_gemma":[0.02982454,0.001568428,0.001587663,0.002075135,0.0008063774,0.001907562,0.0007372585,0.002424281,0.09323991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001353609,"about_ca_system_score_gemma":0.003708407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001925089,"about_ca_topic_score_gemma":0.004476415,"domain_scores_codex":[0.9981054,0.0008934478,0.0003175122,0.0002562619,0.0002225608,0.0002047163],"domain_scores_gemma":[0.9774982,0.01565827,0.002014748,0.001492135,0.00234569,0.0009909989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1000524,0.003611981,0.000632623,0.03846718,0.0007793542,0.0000924331,0.0002006417,0.0008258304,0.0008860074,0.004407576,0.8098146,0.04022934],"study_design_scores_gemma":[0.7206293,0.009363232,0.005992765,0.005663032,0.001085731,0.0002114928,0.0001155919,0.001117562,0.001061801,0.009577184,0.2450162,0.0001661471],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"protocol","genre_scores_codex":[0.003076337,0.0009749223,0.00468133,0.001691921,0.0009070677,0.09181841,0.8805637,0.00145153,0.01483486],"genre_scores_gemma":[0.04217935,0.002226677,0.03488932,0.006451412,0.001288398,0.6674469,0.1826122,0.001106211,0.06179961],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.8286208,"threshold_uncertainty_score":0.2444516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1942515505057596,"score_gpt":0.4795566069451762,"score_spread":0.2853050564394165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}