{"id":"W7102743682","doi":"10.17863/cam.122662","title":"Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer.","year":2025,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Medical Research and Materiel Command; National Center for Advancing Translational Sciences; European Regional Development Fund; Medical Research Council; Canadian Institutes of Health Research; Cancer Center, University of Kansas; University of California, San Francisco; University of California, Los Angeles; National Institutes of Health; National Cancer Institute; Peter MacCallum Foundation; Hellenic Health Foundation; Freistaat Sachsen; Pomorski Uniwersytet Medyczny W Szczecinie; Mutuelle Générale de l'Education Nationale; Health Canada; Fox Chase Cancer Center; Ministero dello Sviluppo Economico; Russian Science Foundation; University of Texas MD Anderson Cancer Center; Institut National Du Cancer; Norges Forskningsråd; Associazione Italiana per la Ricerca sul Cancro; Ministerio de Ciencia e Innovación; Vetenskapsrådet; University of Toronto; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Institut National de la Santé et de la Recherche Médicale; Ministero della Salute; Terry Fox Foundation; Helse Vest; NorthShore University HealthSystem; Department of Health and Social Care; Roswell Park Cancer Institute; National Institute for Health and Care Research; European Commission; Directorate for Biological Sciences; Ovarian Cancer Australia; Swedish Cancer Foundation; Odense Universitetshospital; Israel Cancer Association; Institut Gustave-Roussy; University of Pennsylvania; Lon V. Smith Foundation; Radboud Universiteit; Fundación Mutua Madrileña; Ministère du Développement Économique, de l’Innovation et de l’Exportation; U.S. Department of Defense; Cancer Research UK; Memorial Sloan-Kettering Cancer Center; Wellcome Trust; Kreftforeningen; Cancer Research Society; Kansas Bioscience Authority; Ligue Contre le Cancer; McGill University; Breast Cancer Research Foundation; Univerzita Karlova v Praze; Unicancer; Clalit Health Services; Deutsches Krebsforschungszentrum; Faculty of Medicine, McGill University; Georgetown University; University of Cambridge; University of Pittsburgh; Fondation ARC pour la Recherche sur le Cancer; Istituto Oncologico Veneto; Royal Marsden NHS Foundation Trust; Deutsche Krebshilfe; Lee Foundation; NRG Oncology; Cancer Australia; National Health and Medical Research Council; Jewish General Hospital; Fisher Center for Alzheimer's Research Foundation; Instituto de Salud Carlos III; Ohio State University; NIH Office of the Director; National Medical Research Council; Ministério da Ciência, Tecnologia e Inovação; NIHR Cambridge Biomedical Research Centre; Peter MacCallum Cancer Centre; Princeton Center for Complex Materials; Oregon Health and Science University; European Social Fund; University of Chicago","keywords":"Genome-wide association study; Odds ratio; Ovarian cancer; SNP; Biobank; Genetic association; Serous fluid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004367105,0.0001779948,0.0003184674,0.0005238631,0.0004988232,0.0003932184,0.0002398393,0.0002690368,0.002370366],"category_scores_gemma":[0.0009562635,0.0001697382,0.0002691266,0.001296827,0.0002961445,0.0001219147,0.000325786,0.000268294,0.000284181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000120817,"about_ca_system_score_gemma":0.0002313928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008033344,"about_ca_topic_score_gemma":0.01532386,"domain_scores_codex":[0.9997543,0.00005196439,0.00001871085,0.00006346405,0.00005445769,0.00005713282],"domain_scores_gemma":[0.9995875,0.0001776468,0.00009333836,0.00005117379,0.00002998201,0.00006040952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007607347,0.00003139619,0.986487,0.00003293202,0.0002188696,0.000430192,0.000209699,0.00005205073,0.00540208,0.0001392958,0.0005102682,0.005725447],"study_design_scores_gemma":[0.00004198584,0.00009441592,0.9964097,0.000007720991,0.0001570644,0.0004586724,0.0001531534,0.00006420664,0.000448037,0.00009225006,0.002068687,0.000004102606],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968292,0.0006199947,0.0002254661,0.00009420593,0.000008543876,0.000005313666,0.001099891,0.000009006505,0.00110839],"genre_scores_gemma":[0.9981971,0.0001732926,0.0001725536,0.00005220199,0.000007468777,0.000005217205,0.0006281603,0.000005446725,0.0007584611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008033344,"threshold_uncertainty_score":0.01597315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006192048203017949,"score_gpt":0.2144435128696351,"score_spread":0.2082514646666172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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