{"id":"W7103750084","doi":"10.1161/circ.152.suppl_3.4365531","title":"Abstract 4365531: Acoramidis Effect on All-Cause Mortality in Patients with p.V142I (V122I) Variant ATTR-CM: Findings From the ATTRibute-CM Study","year":2025,"lang":"en","type":"article","venue":"Circulation","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Transthyretin; Placebo; Proportional hazards model; Randomization; Post-hoc analysis; Clinical trial; Randomized controlled trial; Cardiomyopathy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001241851,0.0007476571,0.001681466,0.0002573806,0.0002761271,0.0007437057,0.0004657142,0.001209321,0.004689715],"category_scores_gemma":[0.001495363,0.0002635331,0.002275643,0.000377389,0.0003822008,0.0004604626,0.0003231748,0.001892744,0.000516605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003504099,"about_ca_system_score_gemma":0.0005462168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007520277,"about_ca_topic_score_gemma":0.002056826,"domain_scores_codex":[0.9995395,0.0002196016,0.00005071828,0.00007812324,0.00006098872,0.00005101005],"domain_scores_gemma":[0.9988839,0.0002786135,0.0003261191,0.00009168439,0.0001321757,0.0002875258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8955503,0.008932258,0.0251776,0.001841199,0.004980859,0.0001443018,0.0001154487,0.000357781,0.009844079,0.000183067,0.003476055,0.04939708],"study_design_scores_gemma":[0.6350381,0.1656311,0.1828838,0.000461007,0.007713648,0.0003568624,0.0002032563,0.0009852996,0.002746605,0.0005593624,0.003337716,0.0000832893],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887344,0.006437345,0.0001164659,0.0006126165,0.0002098781,0.0003637348,0.001753475,0.00003689911,0.001735245],"genre_scores_gemma":[0.9940729,0.002245832,0.000343217,0.0005120223,0.0003654303,0.0003129876,0.001294734,0.000006954012,0.0008460035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004689715,"threshold_uncertainty_score":0.01568866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01972889545750863,"score_gpt":0.2898131650675142,"score_spread":0.2700842696100056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}