{"id":"W7103903965","doi":"10.48448/3dwb-1777","title":"Double Trouble: Lynch Syndrome and KRAS Mutation in a Young Male With Stage IV Colon Adenocarcinoma","year":2025,"lang":"","type":"other","venue":"Underline Science Inc.","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario","funders":"","keywords":"Lynch syndrome; KRAS; Microsatellite instability; Colorectal cancer; FOLFOX; Adenocarcinoma; PMS2; Germline mutation; Colonoscopy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001828285,0.00122044,0.0009908401,0.001971884,0.001651407,0.0007136028,0.000582009,0.003158669,0.00288151],"category_scores_gemma":[0.001313345,0.0006589323,0.0008361337,0.0008239158,0.0006718964,0.001222588,0.0007925218,0.002106526,0.0006273621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000742402,"about_ca_system_score_gemma":0.000518175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003635322,"about_ca_topic_score_gemma":0.003808622,"domain_scores_codex":[0.9997267,0.00002468383,0.00002922819,0.00009027022,0.00004537315,0.00008374628],"domain_scores_gemma":[0.9991379,0.000147087,0.0001602821,0.00002208892,0.00005214336,0.0004804343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00005276895,0.00003538816,0.02284438,0.0000205926,0.000008465939,0.975207,0.0001323104,0.00003626048,0.0005953911,0.00004777837,0.0004319606,0.0005877896],"study_design_scores_gemma":[0.000009407206,0.0001431176,0.02621752,0.00002117132,0.00001474437,0.972563,0.0001780764,0.0001846406,0.0001596845,0.00007158075,0.0004224475,0.00001455864],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875478,0.002723145,0.0007582915,0.003705392,0.0003753543,0.0001040615,0.0003247111,0.00008868449,0.004372688],"genre_scores_gemma":[0.9953871,0.0008431039,0.000509861,0.00112504,0.0005534193,0.00001641522,0.0001114496,0.00001448379,0.001439146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003635322,"threshold_uncertainty_score":0.009639561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01557494961839007,"score_gpt":0.27439012929026,"score_spread":0.25881517967187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}