{"id":"W7104179308","doi":"10.1016/j.annonc.2025.08.2109","title":"1479P Safety and efficacy of radiotherapy combined with lenvatinib and sintilimab as neoadjuvant therapy for hepatocellular carcinoma with portal vein tumor thrombus: Interim results of an open-label, single-arm, multicenter, prospective phase I clinical trial","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Object Research Systems (Canada)","funders":"","keywords":"Lenvatinib; Hepatocellular carcinoma; Radiation therapy; Interim; Portal vein; Neoadjuvant therapy; Interim analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001062394,0.0009347991,0.002094955,0.0003902495,0.0002684332,0.001078281,0.000565613,0.00119521,0.004403905],"category_scores_gemma":[0.001075373,0.0004713561,0.001510979,0.0004465422,0.001173282,0.0009297844,0.0002972208,0.002758278,0.001260906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000739769,"about_ca_system_score_gemma":0.001117242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004134984,"about_ca_topic_score_gemma":0.0009550515,"domain_scores_codex":[0.9994897,0.0002792934,0.00002599265,0.00007576447,0.00004821752,0.00008096698],"domain_scores_gemma":[0.9994498,0.0001450266,0.0001539893,0.00006189659,0.00003028764,0.0001591267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8547003,0.01044217,0.005115091,0.0006502888,0.002021168,0.0001384301,0.00007184876,0.001858974,0.01368634,0.000324585,0.002920805,0.10807],"study_design_scores_gemma":[0.6452874,0.3242968,0.01540801,0.00008847065,0.001765836,0.0004451255,0.00008155717,0.002651914,0.006142987,0.0006655116,0.003102946,0.00006340108],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926605,0.002663951,0.0003408135,0.0006683312,0.0002112072,0.000327366,0.0006434277,0.00009539068,0.002389107],"genre_scores_gemma":[0.9934423,0.001503022,0.0006286239,0.0006658632,0.0001961641,0.0005387158,0.001252448,0.000037441,0.001735494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004403905,"threshold_uncertainty_score":0.0147326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1949464068817133,"score_gpt":0.434977104181802,"score_spread":0.2400306973000887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}