{"id":"W7104651094","doi":"10.24433/co.6242481.v1","title":"Protein-protein interactions are a major source of epistasis in genetic interaction networks","year":2025,"lang":"en","type":"other","venue":"Code Ocean","topic":"","field":"","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Epistasis; Gene interaction; Interaction model; Genetic variants; Mutation; Asynchronous communication","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002023568,0.0005924226,0.0008273649,0.001611915,0.00005480122,0.00006237644,0.0005365239,0.0004383916,0.002797538],"category_scores_gemma":[0.0002498155,0.0006626406,0.0002502353,0.0009618195,0.0001368665,0.00008732845,0.0002285284,0.001045695,0.0006946574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005264943,"about_ca_system_score_gemma":0.0001596898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002394617,"about_ca_topic_score_gemma":0.01037719,"domain_scores_codex":[0.9972421,0.0003605452,0.0007893434,0.0007911227,0.0003227012,0.0004941876],"domain_scores_gemma":[0.997392,0.00006773508,0.001269807,0.001026227,0.0001306053,0.0001136147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007088016,0.001163886,0.004301859,0.002094759,0.0009174973,0.0001234774,0.000354482,0.004777618,0.002964656,0.0004090294,0.9644173,0.01776668],"study_design_scores_gemma":[0.001910507,0.0001221038,0.001849851,0.0224865,0.000332238,0.00002423286,0.0005210206,0.008434044,0.002004956,0.0003337789,0.9605969,0.001383858],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.03658951,0.007235029,0.06187725,0.0006912311,0.002828942,0.01603766,0.003280055,0.003040381,0.8684199],"genre_scores_gemma":[0.2651741,0.00002315983,0.001581623,0.000041224,0.0003943203,0.0002063188,0.0001902352,0.00141078,0.7309783],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.2285846,"threshold_uncertainty_score":0.9995825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01420577463855396,"score_gpt":0.2705936294256226,"score_spread":0.2563878547870687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}