{"id":"W7106275839","doi":"10.1007/978-3-031-93616-6_1","title":"20 Clinically Pertinent Factors/Observations for Percutaneous Absorption in Humans","year":2025,"lang":"en","type":"book-chapter","venue":"","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Stratum corneum; Human skin; Absorption (acoustics); Percutaneous; Population; Drug","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003940976,0.0005092989,0.0005978649,0.0002587894,0.0002213451,0.00001677596,0.0004119913,0.00121959,0.005182633],"category_scores_gemma":[0.0001075552,0.0005097912,0.0003539241,0.00004344406,0.0001903975,0.00009448674,0.00009037771,0.001465368,0.000096738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002726199,"about_ca_system_score_gemma":0.0001846936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001153398,"about_ca_topic_score_gemma":0.0002633719,"domain_scores_codex":[0.9974136,0.00007847013,0.001185771,0.0006704216,0.0001908571,0.0004609048],"domain_scores_gemma":[0.9976858,0.001379554,0.000256582,0.0003290347,0.0002130049,0.0001360153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006248559,0.003433166,0.01810827,0.002985117,0.004131298,0.0006362745,0.003939089,0.02025758,0.01534133,0.6062972,0.2369231,0.08169902],"study_design_scores_gemma":[0.00126722,0.0002293469,0.000234693,0.0001327691,0.0004423849,0.000005480329,0.00005553224,0.003062068,0.00009386719,0.01075526,0.9830738,0.0006475251],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.007761398,0.001150803,0.01837463,0.002900259,0.00552491,0.005372703,0.00301764,0.0004591603,0.9554385],"genre_scores_gemma":[0.008217853,0.00183258,0.002295145,0.004988575,0.0003100693,0.000121982,0.00139696,0.00008030125,0.9807565],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.7461508,"threshold_uncertainty_score":0.9997354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2162035653207718,"score_gpt":0.4521497486497137,"score_spread":0.2359461833289419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}