{"id":"W7106318656","doi":"10.1093/jimmun/vkaf283.093","title":"Alterations of Ceramide Synthesis Induce PD-L1 Internalization and Signaling to Regulate Tumor Metastasis and Immunotherapy Response 2131","year":2025,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale; National Institutes of Health; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques","keywords":"Internalization; Immunotherapy; Signal transduction; Immune system; Ceramide; Metastasis; Cancer immunotherapy; Intracellular; Tumor microenvironment","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001131719,0.0002455754,0.0001832067,0.0001955044,0.0001454228,0.0003280005,0.0001197527,0.0002284659,0.001701042],"category_scores_gemma":[0.00007830613,0.0001166038,0.0002162628,0.00007739678,0.0001953401,0.000153867,0.0002180605,0.0005936561,0.0004157173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006029679,"about_ca_system_score_gemma":0.0003076011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003869228,"about_ca_topic_score_gemma":0.0004387556,"domain_scores_codex":[0.9999007,0.00001418906,0.000008943986,0.00001816618,0.00002617542,0.00003174265],"domain_scores_gemma":[0.9999578,0.000003969067,0.0000128755,0.000004188102,0.000007522762,0.00001364987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002323799,0.00003143253,0.0003501789,0.00002246469,0.000004734486,0.00002924895,0.000006793852,0.00009687839,0.9975482,0.0001386856,0.00006956997,0.001469388],"study_design_scores_gemma":[0.00002843609,0.0002503671,0.003191797,0.000003808609,0.000009810235,0.0001153795,0.00002180772,0.001444799,0.9931763,0.00008727056,0.001666853,0.000003312434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937285,0.001319367,0.002000408,0.0001476464,0.00002945776,0.00004235886,0.00026284,0.00008970004,0.002379616],"genre_scores_gemma":[0.9962308,0.0003427655,0.00107783,0.00005555783,0.000005722723,0.00003521496,0.0002418197,0.000007597205,0.002002667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001701042,"threshold_uncertainty_score":0.005690515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00779534118722367,"score_gpt":0.2552202549967172,"score_spread":0.2474249138094936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}