{"id":"W7106491637","doi":"10.5281/zenodo.17704991","title":"Conscience November 2025 Policy Brief - FDA Announces Plan to Alter Regulatory Regime for n-of-1 Gene Editing","year":2025,"lang":"","type":"article","venue":"Zenodo (CERN European Organization for Nuclear Research)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Bespoke; Plan (archaeology); Conscience; Government regulation; Genome editing; Regulatory reform","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009467058,0.001153831,0.0009147719,0.001191348,0.005185571,0.007985052,0.002509251,0.04296687,0.06196692],"category_scores_gemma":[0.02247929,0.001037943,0.001697354,0.001038116,0.002411004,0.003791402,0.002239884,0.01903133,0.05371208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006743275,"about_ca_system_score_gemma":0.0169853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02670683,"about_ca_topic_score_gemma":0.05755005,"domain_scores_codex":[0.9903289,0.0008239677,0.0004058052,0.001096563,0.005738064,0.00160676],"domain_scores_gemma":[0.991198,0.00322443,0.0005251518,0.0005010207,0.003314655,0.00123683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003632324,0.00005985857,0.0001103249,0.00004632513,0.000004860014,0.0001608228,0.00004181963,0.00006429847,0.0003996402,0.02398457,0.9669363,0.008154822],"study_design_scores_gemma":[0.00003750862,0.00004072384,0.0004199867,0.00008281748,0.000006851253,0.00007113914,0.00004094211,0.00008451964,0.0002379998,0.003494166,0.9954605,0.00002296793],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"commentary","genre_scores_codex":[0.001580767,0.003542509,0.00314339,0.318694,0.04124562,0.0007823639,0.003048662,0.001294189,0.6266686],"genre_scores_gemma":[0.00679299,0.001147012,0.001950075,0.3655857,0.004884293,0.0006166981,0.0008460997,0.0002451603,0.6179319],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.06196692,"threshold_uncertainty_score":0.2073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01774984796456315,"score_gpt":0.2951845464370402,"score_spread":0.277434698472477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}