{"id":"W7108444082","doi":"10.1182/blood-2025-2288","title":"A Phase 2/3, multicenter, randomized, open-label study evaluating the efficacy and safety of etentamig and daratumumab compared to daratumumab, lenalidomide, and dexamethasone in frailer transplant-ineligible patients with newly diagnosed multiple myeloma","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Daratumumab; Multiple myeloma; Dexamethasone; Monoclonal antibody; Monoclonal; Phases of clinical research; Antibody; Clinical trial","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002685956,0.001523706,0.002723679,0.0002858783,0.0005689291,0.001223966,0.000819952,0.001573231,0.005858628],"category_scores_gemma":[0.001670772,0.0006443412,0.002257774,0.0004101672,0.001242925,0.001522986,0.0004816655,0.004041823,0.001046071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009452434,"about_ca_system_score_gemma":0.001486003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005529019,"about_ca_topic_score_gemma":0.001393244,"domain_scores_codex":[0.9993286,0.0003109037,0.00004710213,0.0001575568,0.00005385597,0.0001020686],"domain_scores_gemma":[0.9984687,0.0003237982,0.0003736133,0.0001356991,0.000120225,0.0005778841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9664546,0.01694241,0.001484734,0.000370659,0.001207118,0.00004446697,0.00005653651,0.0002977355,0.002788184,0.00007778338,0.0005290758,0.009746746],"study_design_scores_gemma":[0.8510432,0.1436635,0.003188687,0.00002267355,0.0005491585,0.0000467551,0.00002414261,0.0003524175,0.0003411634,0.0001239308,0.0006283806,0.00001611042],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899778,0.003330811,0.000554861,0.0004982201,0.0003339333,0.003444386,0.0008899014,0.00005760704,0.0009123694],"genre_scores_gemma":[0.9877259,0.001537885,0.00157183,0.001419096,0.0003622691,0.004611162,0.001166305,0.00001862911,0.001586899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005858628,"threshold_uncertainty_score":0.01959908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04428676901334626,"score_gpt":0.3690392358046509,"score_spread":0.3247524667913047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}