{"id":"W7108452047","doi":"10.5267/j.ccl.2025.11.003","title":"Thiazolo[3,2-a]pyrimidines: synthesis methods and biomedical potential","year":2025,"lang":"","type":"article","venue":"Current Chemistry Letters","topic":"Synthesis and Reactivity of Heterocycles","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Purine; Cycloaddition; Purine analogue; Microwave chemistry; Biomimetic synthesis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007868791,0.001025834,0.001227106,0.0001589115,0.0005537178,0.0003654947,0.0008952583,0.0007796533,0.001687614],"category_scores_gemma":[0.001127197,0.001014272,0.0006568775,0.0003175187,0.001611709,0.0002032953,0.0006693415,0.001318418,0.0000307305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002919819,"about_ca_system_score_gemma":0.0002418666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001992589,"about_ca_topic_score_gemma":2.385076e-7,"domain_scores_codex":[0.9951094,0.0002161124,0.001079788,0.001701995,0.000620315,0.001272431],"domain_scores_gemma":[0.9964329,0.001385412,0.0004374448,0.001099822,0.00007745436,0.0005669724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000838531,0.0005270203,0.0002544992,0.003963535,0.000468895,0.00002983233,0.00009211987,0.000003318363,0.7354843,0.000005223048,0.003830516,0.2552569],"study_design_scores_gemma":[0.0008002468,0.000002003463,0.0003200908,0.002470874,0.001044328,0.00007920346,0.0004155342,0.001169066,0.956919,0.00008733857,0.03571263,0.0009797132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9564022,0.01737303,0.005759623,0.01615503,0.002195323,0.0001927029,0.0001283227,0.0001997615,0.001593948],"genre_scores_gemma":[0.9915071,0.00353829,0.002639803,0.0002452932,0.001621807,0.0001135804,0.00006554931,0.00009484924,0.0001737424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2542771,"threshold_uncertainty_score":0.9992307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01353131639590236,"score_gpt":0.3205573250527976,"score_spread":0.3070260086568952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}