{"id":"W7108461223","doi":"10.1182/blood-2025-7647","title":"BCMA-targeted CAR-NK cell therapy using lipid nanoparticle mRNA delivery for multiple myeloma","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Alberta","funders":"","keywords":"Chimeric antigen receptor; Multiple myeloma; Genetic enhancement; Immunogenicity; Cancer; Cell therapy; Cytokine release syndrome; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006168547,0.000202019,0.0001797203,0.0001186653,0.0001141167,0.0002033632,0.0001227998,0.0003003287,0.001603779],"category_scores_gemma":[0.00005120982,0.00007188062,0.0001895968,0.0000952413,0.0001214148,0.0001705481,0.0002078341,0.0003260348,0.0005251347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004982618,"about_ca_system_score_gemma":0.0002463857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001073756,"about_ca_topic_score_gemma":0.0008607035,"domain_scores_codex":[0.9999578,0.000003968226,0.000001814065,0.00001159662,0.00001447875,0.00001036421],"domain_scores_gemma":[0.9999888,0.000001543139,0.000003310628,8.83317e-7,0.000003006279,0.000002506676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001687104,0.0000701507,0.00007429416,0.0001895446,0.000008757309,0.0001221481,0.00002157566,0.0008150397,0.9740512,0.0004352264,0.0006780067,0.02336529],"study_design_scores_gemma":[0.00006622458,0.0007739053,0.0005959459,0.00001744603,0.00004227118,0.0002849211,0.00001737495,0.006492947,0.9740504,0.0002024137,0.01744488,0.00001128388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9000202,0.03220426,0.04912332,0.001247981,0.0006065384,0.0002295285,0.0003342584,0.0007499616,0.01548384],"genre_scores_gemma":[0.9795171,0.005824821,0.006103985,0.0002338091,0.00003587469,0.00008578483,0.0001291129,0.00003618691,0.00803334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001603779,"threshold_uncertainty_score":0.005365193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03345951169619087,"score_gpt":0.3009155936766589,"score_spread":0.267456081980468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}