{"id":"W7108469148","doi":"10.1182/blood-2025-3425","title":"Phase 1 study of revumenib in combination with intensive chemotherapy (IC) in patients (Pts) with newly diagnosed (ND) Acute Myeloid Leukemia (AML) harboring genetic alterations in KMT2A, NPM1, or NUP98: SNDX-5613-0708","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; McGill University","funders":"","keywords":"Daunorubicin; NPM1; Myeloid leukemia; Cohort; Phases of clinical research; Chemotherapy regimen; Chemotherapy; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006202482,0.0009383189,0.001456791,0.0002547505,0.0002336793,0.000855231,0.0006534686,0.0007496293,0.003947178],"category_scores_gemma":[0.0005006598,0.0003349386,0.0007569379,0.0003182834,0.0004809476,0.0004593324,0.000308969,0.002901768,0.0009387987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009061879,"about_ca_system_score_gemma":0.001402505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001186644,"about_ca_topic_score_gemma":0.003759866,"domain_scores_codex":[0.9997975,0.00008029522,0.00001094185,0.0000429996,0.00002353493,0.00004478237],"domain_scores_gemma":[0.9996806,0.00004039035,0.00006704602,0.00002798212,0.00002851786,0.0001554284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4529165,0.102379,0.018248,0.002025788,0.002493701,0.0006097002,0.0004750071,0.007584915,0.1108061,0.0009137072,0.01749576,0.2840519],"study_design_scores_gemma":[0.3307476,0.6182826,0.02270867,0.00009144327,0.0008689127,0.001052451,0.0001096297,0.001980607,0.01018303,0.0004035616,0.013521,0.0000506106],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872228,0.002961196,0.0006949083,0.0005436945,0.0001383656,0.002422753,0.002046503,0.0001714954,0.003798302],"genre_scores_gemma":[0.9833978,0.00268337,0.002129525,0.0009257882,0.0001488741,0.001936422,0.00461479,0.00004325994,0.004120067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003947178,"threshold_uncertainty_score":0.01320457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0143661173990195,"score_gpt":0.2948597779002626,"score_spread":0.2804936605012431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}