{"id":"W7108477400","doi":"10.5061/dryad.vt4b8gv5x","title":"<i>MSH3</i> is a genetic modifier of somatic repeat instability in X-linked dystonia parkinsonism","year":2025,"lang":"en","type":"dataset","venue":"Open MIND","topic":"","field":"","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Care Foundation","funders":"","keywords":"Trinucleotide repeat expansion; Exome sequencing; Somatic cell; Parkinsonism; Allele; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001250068,0.0001901537,0.0001290465,0.0003491215,0.0001609574,0.0001387933,0.000100482,0.0002364762,0.001763923],"category_scores_gemma":[0.0002076565,0.00007392508,0.0001457726,0.0002537712,0.0001498907,0.00006417581,0.0001419944,0.0002289252,0.0001406922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001572676,"about_ca_system_score_gemma":0.00005984904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009259128,"about_ca_topic_score_gemma":0.001565275,"domain_scores_codex":[0.9999077,0.00001363235,0.00001069812,0.00003088142,0.00002514277,0.00001185021],"domain_scores_gemma":[0.9998363,0.00003359101,0.00007918683,0.00001071795,0.00001209826,0.00002802456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001049912,0.0000470939,0.08455233,0.00003513442,0.00006601786,0.001154494,0.00006561558,0.0002398123,0.9057898,0.0001625895,0.0002255868,0.006611697],"study_design_scores_gemma":[0.00002660826,0.0002169139,0.9073574,0.00001017312,0.00004977747,0.003975044,0.00006048165,0.001691875,0.08546089,0.0001626616,0.0009771051,0.00001119135],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"dataset","genre_scores_codex":[0.9985649,0.0001200689,0.0006223962,0.00004058732,0.0000040634,0.00000521755,0.0003387991,0.000019498,0.0002845094],"genre_scores_gemma":[0.9992386,0.00002396115,0.0003413164,0.00002744132,0.000004348701,0.00000287231,0.0001541932,0.000006237288,0.0002009699],"genre_candidate":"dataset","genre_consensus":null,"teacher_disagreement_score":0.001763923,"threshold_uncertainty_score":0.00590086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03770591115873834,"score_gpt":0.3254268717511769,"score_spread":0.2877209605924386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}