{"id":"W7108512155","doi":"10.1182/blood-2025-3431","title":"Trial in progress: A phase I study evaluating the safety of cirtuvivint (CIRT) as monotherapy and in combination with ASTX727 in patients with myelodysplastic syndromes (MDS) and Acute Myeloid Leukemia (AML)","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick","funders":"","keywords":"Venetoclax; Decitabine; Myelodysplastic syndromes; Combination therapy; Salvage therapy; Refractory (planetary science); Clinical trial; Cancer; Phases of clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002829575,0.002362645,0.002326657,0.0004473536,0.0005878032,0.001566206,0.001439962,0.002072881,0.006115082],"category_scores_gemma":[0.001375757,0.0007953403,0.001581692,0.0005322019,0.001603527,0.001397415,0.0004565276,0.00549576,0.001721261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001000921,"about_ca_system_score_gemma":0.002145416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006861204,"about_ca_topic_score_gemma":0.001536657,"domain_scores_codex":[0.9992441,0.0004199202,0.00002638862,0.0001067642,0.00006041827,0.0001424401],"domain_scores_gemma":[0.9986455,0.0001549192,0.0002155188,0.0001390886,0.00009852539,0.0007465127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8441184,0.07221843,0.003361082,0.0006694483,0.001142191,0.0002760781,0.0002823498,0.001805106,0.02760331,0.0005739188,0.00518934,0.04276028],"study_design_scores_gemma":[0.6209508,0.3704063,0.003141591,0.0000232916,0.0002284817,0.0001844114,0.00005231632,0.0008402852,0.001714111,0.0002615399,0.002174197,0.00002264615],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799672,0.002378338,0.001319709,0.001201574,0.0003624905,0.007278921,0.003123849,0.000263886,0.004104216],"genre_scores_gemma":[0.9657009,0.002539971,0.004426755,0.002216335,0.0005528982,0.01057444,0.006706054,0.00008122691,0.007201372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006115082,"threshold_uncertainty_score":0.02045697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01478741614110695,"score_gpt":0.3297274307720428,"score_spread":0.3149400146309358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}